864277-08-7Relevant articles and documents
Synthesis of Biaryls Having a Piperidylmethyl Group Based on Space Integration of Lithiation, Borylation, and Suzuki–Miyaura Coupling
Aizawa, Yoko,Ashikari, Yosuke,Colella, Marco,Fujita, Chiemi,Higuma, Ryosuke,Ishikawa, Susumu,Jiang, Yiyuan,Luisi, Renzo,Maekawa, Kei,Nagaki, Aiichiro,Sakaue, Hodaka,Shimizu, Yutaka,Shite, Ibuki,Takahashi, Yusuke,Takegawa, Toshihiro,Takumi, Masahiro,Yamashita, Hiroki,Yonekura, Yuya
supporting information, p. 618 - 622 (2020/02/04)
In a flow microreactor, aryllithiums bearing a piperidylmethyl group were generated using nBuLi by precise residence time control and effective temperature control, and then selectively borylated with boronic esters such as 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (BpinOiPr) and trimethyl borate B(OMe)3 by fast mixing. Moreover, the direct integration with Suzuki–Miyaura cross coupling were successfully achieved to obtain nitrogen-containing biaryl compounds. The present method could be applied for the straightforward synthesis of the key intermediate of a bioactive component bearing a piperidylmethyl-biphenyl framework.