864514-17-0

Basic information

• Product Name: Benzoic acid, 4,6-bis[(4-methoxyphenyl)methoxy]-3-methyl-2-(2-oxoethyl)-, methyl ester
• CAS NO: 864514-17-0
• Molecular Formula: C27H28O7
• Molecular Weight: 464.515
• Mol File: 864514-17-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4,6-bis[(4-methoxyphenyl)methoxy]-3-methyl-2-(2-oxoethyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4,6-bis[(4-methoxyphenyl)methoxy]-3-methyl-2-(2-oxoethyl)-, methyl ester(864514-17-0)
• EPA Substance Registry System: Benzoic acid, 4,6-bis[(4-methoxyphenyl)methoxy]-3-methyl-2-(2-oxoethyl)-, methyl ester(864514-17-0)

Safety Data

• Hazardous Substances Data: 864514-17-0(Hazardous Substances Data)

Upstream product

• 2150-47-2 methyl 2,4-dihydroxybenzoate 
• 38064-90-3 2,4-dimethoxytoluene 
• 50625-55-3 5-methyl-2,4-dimethoxy-benzoic acid 
• 7149-91-9 2,4-dimethoxy-5-methyl-benzaldehyde 
• 864514-40-9 2-allyl-4,6-bis-(4-methoxy-benzyloxy)-3-methyl-benzoic acid methyl ester 
• 864514-21-6 2-allyl-N,N-diethyl-4,6-dimethoxy-3-methyl-benzamide 
• 864514-38-5 2-allyl-N,N-diethyl-4,6-dihydroxy-3-methyl-benzamide 
• 864514-39-6 methyl 2-allyl-4,6-dihydroxy-3-methylbenzoate 
• 864514-37-4 N,N-diethyl-2,4-dimethoxy-5-methyl-benzamide 

Downstream Products

• 864514-27-2 2-{(2R,3S)-5-[(2R,4R,6S)-4-(tert-Butyl-dimethyl-silanyloxy)-6-cyano-3,3-dimethyl-tetrahydro-pyran-2-yl]-2-hydroxy-3-methyl-4-oxo-pentyl}-4,6-bis-(4-methoxy-benzyloxy)-3-methyl-benzoic acid methyl ester 
• 1402588-86-6 C₅₀H₇₉NO₁₂Si₂ 
• 1402588-85-5 C₅₈H₈₇NO₁₃Si₂ 
• 1402588-84-4 C₅₁H₈₃NO₁₂Si₂ 
• 1402589-26-7 C₅₁H₈₃NO₁₂Si₂ 
• 1402588-83-3 C₄₁H₆₃NO₉Si₂ 
• 1402588-81-1 C₄₂H₆₇NO₉Si₂ 
• 1402588-80-0 C₅₀H₇₅NO₁₀Si₂ 
• 1402588-79-7 C₅₀H₇₃NO₉Si₂ 
• 864514-28-3 (2S,4R,6R)-6-{(2S,3R)-3-[(R)-6,8-Bis-(4-methoxy-benzyloxy)-5-methyl-1-oxo-isochroman-3-yl]-2-hydroxy-butyl}-4-(tert-butyl-dimethyl-silanyloxy)-5,5-dimethyl-tetrahydro-pyran-2-carbonitrile 
• 864514-30-7 (2S,4R,6R)-6-{(2S,3R)-3-[(R)-6,8-Bis-(4-methoxy-benzyloxy)-5-methyl-1-oxo-isochroman-3-yl]-2-hydroxy-butyl}-4-hydroxy-5,5-dimethyl-tetrahydro-pyran-2-carboxylic acid amide 
• 864514-29-4 (2S,4R,6R)-6-{(2S,3R)-3-[(R)-6,8-Bis-(4-methoxy-benzyloxy)-5-methyl-1-oxo-isochroman-3-yl]-2-hydroxy-butyl}-4-hydroxy-5,5-dimethyl-tetrahydro-pyran-2-carbonitrile 

Relevant articles and documents

Entry to 1,2,3,4-Tetrasubstituted Arenes through Addressing the " Meta Constraint" in the Palladium/Norbornene Catalysis

Arenes with four different contiguous substituents, i.e. 1,2,3,4-tetrasubstituted arenes, are commonly found in bioactive compounds, but they are nontrivial to access via conventional methods. Through addressing the "meta constraint" in the palladium/norbornene (Pd/NBE) cooperative catalysis, which is the difficulty of tolerating a sizable meta substituent in aryl halide substrates, here a modular and regioselective approach is realized for preparing 1,2,3,4-tetrasubstituted arenes. One key is the use of a C2-amide-substituted NBE, and a combined experimental and computational study reveals its role in promoting the NBE insertion and the ortho C-H metalation steps. The scope is broad: A variety of electrophiles and nucleophiles could be introduced to the ortho and ipso positions, respectively, with 1,4-disubstituted aryl halides, leading to diverse unsymmetrical contiguous tetrasubstituted arenes. Application of this approach has been demonstrated in streamlined syntheses of several bioactive compounds.

Synthesis and complete stereochemical assignment of psymberin/irciniastatin for use as antitumor compounds

The invention relates to the synthesis and complete stereochemical assignments of cytotoxic compounds such as compound 28-a and its stereoisomers: The invention further provides processes for making the compounds, their synthetic intermediates, and for me