864830-05-7

Basic information

• Product Name: tert-butyl 4-(2-chlorophenyl)-5,6-dihydropyridine-1(2H)-carboxylate
• Synonyms: tert-butyl 4-(2-chlorophenyl)-5,6-dihydropyridine-1(2H)-carboxylate
• CAS NO: 864830-05-7
• Molecular Weight: 293.793
• Mol File: 864830-05-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: tert-butyl 4-(2-chlorophenyl)-5,6-dihydropyridine-1(2H)-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-(2-chlorophenyl)-5,6-dihydropyridine-1(2H)-carboxylate(864830-05-7)
• EPA Substance Registry System: tert-butyl 4-(2-chlorophenyl)-5,6-dihydropyridine-1(2H)-carboxylate(864830-05-7)

Safety Data

• Hazardous Substances Data: 864830-05-7(Hazardous Substances Data)

Upstream product

• 615-41-8 2-iodochlorobenzene 
• 375853-82-0 tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate 
• 138647-49-1 4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 

Downstream Products

• 97429-96-4 4-(2-chlorophenyl)-1,2,3,6-tetrahydropyridine 
• 97429-95-3 4-(2-chlorophenyl)-1,2,3,6-tetrahydropyridine hydrochloride 
• 100129-35-9 4-(2-chlorophenyl)piperidine 

Relevant articles and documents

BENZISOXAZOLE COMPOUND

The present invention provides a compound, a salt thereof, or a prodrug thereof as a compound effective for preventing and/or treating fibrosis, the compound being represented by formula (1) (wherein A is an optionally substituted benzene ring; B is optionally substituted aryl or optionally substituted heteroaryl; X is an oxygen atom or a sulfur atom; Y is a nitrogen atom or a carbon atom; ------ of -----Y is a single or double bond when Y is a carbon atom, or ------ of -----Y is a single bond when Y is a nitrogen atom; each R1 independently represents lower alkyl, or two R1s may be bound to each other to form a spiro ring or a crosslinked structure, or two R1s may be bound to each other to form a saturated fused heterocycle together with nitrogen and carbon atoms constituting a ring containing Y; p is 0, 1, or 2; or (R1)p is oxo) .

Design, synthesis, and evaluation of novel aryl-tetrahydropyridine PPARα/γ dual agonists

Aryl-tetrahydropyridine derivatives were prepared and their PPARα/γ dual agonistic activities were evaluated. Among them, compound (S)-5b was identified as a potent PPARα/γ dual agonist with an EC50 of 1.73 and 0.64 μM in hPPARα and γ, respectively. In diabetic (db/db) mice, compound (S)-5b showed good glucose lowering efficacy and favorable pharmacokinetic properties.