865777-21-5

Basic information

• Product Name: tert-butyl-(3-methoxy-3-phenyl-propoxy)-dimethyl-silane
• Synonyms: tert-butyl-(3-methoxy-3-phenyl-propoxy)-dimethyl-silane
• CAS NO: 865777-21-5
• Molecular Weight: 280.483
• Mol File: 865777-21-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl-(3-methoxy-3-phenyl-propoxy)-dimethyl-silane(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl-(3-methoxy-3-phenyl-propoxy)-dimethyl-silane(865777-21-5)
• EPA Substance Registry System: tert-butyl-(3-methoxy-3-phenyl-propoxy)-dimethyl-silane(865777-21-5)

Safety Data

• Hazardous Substances Data: 865777-21-5(Hazardous Substances Data)

Upstream product

• 4407-36-7 (2E)-3-phenyl-2-propen-1-ol 
• 103548-16-9 (R)-3-phenyl-1,3-dihydroxypropane 
• 104196-23-8 (2S,3S)-2,3-epoxy-3-phenyl-1-propanol 

Downstream Products

• 865777-22-6 (R)-3-methoxy-3-phenyl-propionaldehyde 
• 865789-42-0 (R)-3-Methoxy-3-phenyl-propan-1-ol 

Relevant articles and documents

Identification of potent type I MetAPs inhibitors by simple bioisosteric replacement. Part 2: SAR studies of 5-heteroalkyl substituted TCAT derivatives

Systematic SAR studies on the thiazole ring 5-substituent of TCAT derivatives revealed that the introduction of a β-alkoxy or an amino group enhanced the inhibitory activity significantly. The present compounds are representative of specific Co(II)-MetAP1 inhibitors. Before the physiologically relevant metal ions for MetAPs are established, these small molecular compounds could be used as tools for detailed biological studies.