865869-25-6

Basic information

• Product Name: Methanesulfonic acid, trifluoro-, 4-(trifluoromethyl)-1-cyclohexen-1-yl ester
• CAS NO: 865869-25-6
• Molecular Formula: C8H8F6O3S
• Molecular Weight: 298.206
• Mol File: 865869-25-6.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Methanesulfonic acid, trifluoro-, 4-(trifluoromethyl)-1-cyclohexen-1-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Methanesulfonic acid, trifluoro-, 4-(trifluoromethyl)-1-cyclohexen-1-yl ester(865869-25-6)
• EPA Substance Registry System: Methanesulfonic acid, trifluoro-, 4-(trifluoromethyl)-1-cyclohexen-1-yl ester(865869-25-6)

Safety Data

• Hazardous Substances Data: 865869-25-6(Hazardous Substances Data)

Upstream product

• 37595-74-7 N,N-phenylbistrifluoromethane-sulfonimide 
• 75091-99-5 4-(trifluoromethyl)cyclohexan-1-one 
• 145100-51-2 N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulphonyl]methanesulphonamide 

Downstream Products

• 683242-93-5 4,4,5,5-tetramethyl-2-(4-(trifluoromethyl)cyclohex-1-en-1-yl)-1,3,2-dioxaborolane 
• 1128268-27-8 Ethyl 4-[4-(trifluoromethyl)cyclohex-1-en-1-yl]benzoate 
• 1590397-67-3 2-(4-fluoro-N-isopropylphenylsulfonamido)-N-((6-(4-(trifluoromethyl)cyclohex-1-enyl)pyrimidin-4-yl)methyl)acetamide 
• 1590398-38-1 [6-[4-(trifluoromethyl)cyclohex-1-en-1-yl]pyrimidin-4-yl]methanamine 
• 1590398-37-0 2-([6-[4-(trifluoromethyl)cyclohex-1-en-1-yl]pyrimidin-4-yl]methyl)2,3-dihydro-1H-isoindole-1,3-dione 
• 1590398-36-9 [6-[4-(trifluoromethyl)cyclohex-1-en-1-yl]pyrimidin-4-yl]methanol 
• 1590398-35-8 methyl 6-(4-(trifluoromethyl)cyclohex-1-enyl)pyrimidine-4-carboxylate 
• 683243-45-0 6-(trifluoromethyl)-4-(4-(trifluoromethyl)cyclohex-1-enyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1H-benzo[d]imidazole 
• 862461-74-3 N-{4-[6-(4-trifluoromethyl-cyclohex-1-enyl)-pyrimidin-4-yloxy]-benzothiazol-2-yl}-acetamide 

Relevant articles and documents

Multimetallic Ni- and Pd-Catalyzed Cross-Electrophile Coupling to Form Highly Substituted 1,3-Dienes

The synthesis of highly substituted 1,3-dienes from the coupling of vinyl bromides with vinyl triflates is reported for the first time. The coupling is catalyzed by a combination of (5,5′-bis(trifluoromethyl)-2,2′-bipyridine)NiBr2 and (1,3-bis(diphenylphosphino)propane)PdCl2 in the presence of a zinc reductant. This method affords tetra- and penta-substituted 1,3-dienes that would otherwise be difficult to access and tolerates electron-rich and -poor substituents, heterocycles, an aryl bromide, and a pinacol boronate ester. Mechanistically, the reaction appears to proceed by an unusual zinc-mediated transfer of a vinyl group between the nickel and palladium centers.

SUBSTITUTED SULFONAMIDE COMPOUNDS

The invention is concerned with the compounds of formula (I), and salts thereof, wherein X, Y, Z, R1, R2, R3, R3, R4, R5 and R6 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of Formula (I) as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

SOLUBLE GUANYLATE CYCLASE ACTIVATORS

A compound having the structure useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, angina pectoris, thromboses, restenoses, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver in a human or animal patient.