86626-97-3Relevant articles and documents
Discovery of Novel Pyrimidine-Based Capsid Assembly Modulators as Potent Anti-HBV Agents
Kim, Woochan,Kang, Jung-Ah,Park, Minji,Jeong, Pyeong-Hwa,Kim, Yoon Jun,Cho, Yuri,Park, Sung-Gyoo,Kim, Yong-Chul
, p. 5500 - 5518 (2021/05/31)
Core assembly modulators of viral capsid proteins have been developed as an effective treatment of chronic hepatitis B virus (HBV) infection. In this study, we synthesized novel potent pyrimidine derivatives as core assembly modulators, and their antivira
The first example of the Fischer-Hepp type rearrangement in pyrimidines
Cikotiene, Inga,Jonusis, Mantas,Jakubkiene, Virginija
supporting information, p. 1819 - 1825 (2013/10/22)
A N-nitroso moiety can be used for the activation of chloropyrimidines toward a nucleophilic substitution reaction with amines. The subsequent treatment of the obtained products with aq H2SO4 can lead to either N-denitrosation to obtain 4,6-pyrimidinediamines or to a Fischer-Hepp type rearrangement to obtain 5-nitroso-4,6-pyrimidinediamines. It was found that the outcome of the reaction strongly depends on the structure of the pyrimidines. Activation of the pyrimidine ring by three groups with a positive mesomeric effect is crucial for the intramolecular nitroso group migration.
Copper-mediated coupling of aminopurines and aminopyrimidines with arylboronic acids
Joshi, Ramesh A.,Patil, Pratap S.,Muthukrishnan,Ramana,Gurjar, Mukund K.
, p. 195 - 197 (2007/10/03)
Selective N-arylation of aminopurines and aminopyrimidines 1-3 with arylboronic acids 4-6 was explored using copper(II) acetate and the corresponding N-arylated purine and pyrimidine derivatives 7-15 were obtained in moderate to good yields.
