866823-73-6 Usage
Description
Biphenylindanone A (BINA) is a positive allosteric modulator of the metabotropic glutamate receptor 2 (mGluR2), a Gi/o-coupled receptor expressed on presynaptic nerve terminals that modulates the release of neurotransmitters like glutamate and GABA. With its selectivity for mGluR2, robust in vivo activity, and brain penetrance, BINA is a promising compound for studying the role of mGluR2 in various neurological and psychiatric conditions.
Uses
Used in Pharmaceutical Research:
Biphenylindanone A is used as a research tool for elucidating the role of mGluR2 in diverse processes such as psychosis, schizophrenia, and drug addiction. Its selectivity and brain penetrance make it a valuable compound for investigating the therapeutic potential of mGluR2 modulation in these conditions.
Used in Drug Development:
Biphenylindanone A is used as a lead compound in the development of new drugs targeting mGluR2 for the treatment of neurological and psychiatric disorders. Its potent stimulation of human and rat mGluR2 receptors, with EC50 values of 33.2 and 96 nM respectively, highlights its potential as a starting point for designing more effective and selective mGluR2 modulators.
Used in Neurotransmission Studies:
Biphenylindanone A is used as a probe to study the modulation of neurotransmitter release by mGluR2, providing insights into the underlying mechanisms of glutamate and GABA signaling in the central nervous system. This can contribute to a better understanding of synaptic function and the development of targeted therapies for various neurological conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 866823-73-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,6,8,2 and 3 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 866823-73:
(8*8)+(7*6)+(6*6)+(5*8)+(4*2)+(3*3)+(2*7)+(1*3)=216
216 % 10 = 6
So 866823-73-6 is a valid CAS Registry Number.
866823-73-6Relevant articles and documents
INDANONE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS
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Page/Page column 55, (2008/06/13)
The present invention is directed to compounds which are potentiators of metabotropic glutamate receptors, including the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutama
Biphenyl-indanones: Allosteric potentiators of the metabotropic glutamate subtype 2 receptor
Bonnefous, Celine,Vernier, Jean-Michel,Hutchinson, John H.,Gardner, Michael F.,Cramer, Merryl,James, Joyce K.,Rowe, Blake A.,Daggett, Lorrie P.,Schaffhauser, Herve,Kamenecka, Theodore M.
, p. 4354 - 4358 (2007/10/03)
We have identified and synthesized a series of biphenyl-carboxylic acid indanones as allosteric potentiators of the metabotropic glutamate receptor 2. Structure-activity relationship studies directed toward improving the potency and the brain to plasma ra
