868280-59-5Relevant articles and documents
INHIBITORS OF AKT ACTIVITY
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Page/Page column 47, (2010/02/14)
The present invention is directed to compounds which contain substituted pyridazines and pyrimidines moieties which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.