869114-39-6Relevant articles and documents
Further structure-activity relationship studies on 4-((((3 S,6 S)-6-benzhydryltetrahydro-2 H -pyran-3-yl)amino)methyl)phenol: Identification of compounds with triple uptake inhibitory activity as potential antidepressant agents
Gopishetty, Bhaskar,Hazeldine, Stuart,Santra, Soumava,Johnson, Mark,Modi, Gyan,Ali, Solav,Zhen, Juan,Reith, Maarten,Dutta, Aloke
, p. 2924 - 2932 (2011/06/25)
To investigate structural alterations of the lead triple uptake inhibitor molecule, disubstituted 4-((((3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-yl)amino) methyl)phenol, we have carried out structure-activity relationship (SAR) studies to investigate the
TRI-SUBSTITUED 2-BENZHYDRYL-5-BENZLAMINO-TETRAHYDRO-PYRAN-4-OL AND 6-BENZHYDRYL-4-BENZYLAMINO-TETRAHYDRO-PYRAN-3-OL ANALOGUES, AND NOVEL 3,6-DISUBSTITUTED PYRAN DERIVATIVES
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Page/Page column 61; Sheet 10, (2008/06/13)
Novel 3,6-disubstituted pyrans, optionally with a further substituent at the 4-position, are monoamine reuptake inhibitors with activity profiles of anti- depressants.