869782-94-5

Basic information

• Product Name: 5-TRIFLUOROMETHOXY-1H-INDAZOLE-3-CARBOXYLIC ACID
• Synonyms: 5-TRIFLUOROMETHOXY-1H-INDAZOLE-3-CARBOXYLIC ACID;5-TRIFLUOROMETHOXYL-3-INDAZOLE-CARBOXYLIC ACID;5-(Trifluoromethoxy)-1H-indazole-3-carboxylic acidcarboxylic acid;1H-Indazole-3-carboxylicacid, 5-(trifluoroMethoxy)-
• CAS NO: 869782-94-5
• Molecular Formula: C9H5F3N2O3
• Molecular Weight: 246.14
• Product Categories: Indazoles
• Mol File: 869782-94-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-TRIFLUOROMETHOXY-1H-INDAZOLE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-TRIFLUOROMETHOXY-1H-INDAZOLE-3-CARBOXYLIC ACID(869782-94-5)
• EPA Substance Registry System: 5-TRIFLUOROMETHOXY-1H-INDAZOLE-3-CARBOXYLIC ACID(869782-94-5)

Safety Data

• Hazardous Substances Data: 869782-94-5(Hazardous Substances Data)

Usage

General Description

5-TRIFLUOROMETHOXY-1H-INDAZOLE-3-CARBOXYLIC ACID is a chemical compound with the molecular formula C9H5F3N2O3. It is a derivative of indazole and is characterized by the presence of a trifluoromethoxy group and a carboxylic acid group on the indazole ring. 5-TRIFLUOROMETHOXY-1H-INDAZOLE-3-CARBOXYLIC ACID has potential applications in medicinal chemistry, particularly in the development of pharmaceuticals and agrochemicals. It may also be used as a building block in organic synthesis for the production of other chemical compounds. However, its specific properties and uses would need to be further investigated and researched.

Upstream product

• 1221150-40-8 N-amino-3,3-diethoxy-5-trifluoromethoxyisatin 
• 169037-23-4 5-trifluoromethoxy-1H-indole-2,3-dione 

Downstream Products

• 932041-12-8 methyl 5-(trifluoromethoxy)-1H-indazole-3-carboxylate 

Relevant articles and documents

ANTICANCER AGENT

An anticancer agent comprising a compound represented by the formula (I) [R1 represents hydrogen atom, hydroxyl group, a C1-6alkoxy group and the like; R2 and R3 represents hydrogen atom, a halogen atom, a C1-6alkyl group and the like; R4 represents hydrogen atom, a C1-6alkyl group, a C1-6alkylsulfonyl group and the like; R5 represents hydrogen atom or a substituent; .... represents a single bond or a double bond; R6 and R7 represents hydrogen atom, a C1-6alkyl group and the like; R8 represents hydrogen atom, a C1-6alkyl group and the like; A represents -O-, -S-, or - CH2-; D represents -C= or -N=; X represents methylene group, -O-, or -CO-; Q represents -N= or -C(R8)=; and Y represents a heterocyclic group or amino group], which shows a superior inhibitory activity against pim-1 kinase.

DIAZONIUM-FREE METHOD TO MAKE AN INDAZOLE INTERMEDIATE IN THE SYNTHESIS OF BICYCLIC 5-(TRIFLUORMETHOXY)-1H-3-INDAZOLECARBOXYLIC ACID AMIDES

The present invention provides novel methods for preparing 5-(trifluoromethoxy)-lH-3- indazolecarboxylic acid (3), which is a useful precursor for the preparation of bicyclic-5- trifluoromethoxy-lH-indazole-S-carboxylic acid amides of Formula (1).Compounds of Formula (1) are active as agonists and partial agonists of the nicotinic alpha-7 receptor and are being studied for their use in the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain, such as for the treatment of Alzheimer's disease and schizophrenia, as well as other psychiatric and neurological disorders.The present methods are useful for preparing compound (3) on scale up levels

Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof

The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nACh receptors), activation of nACh receptors, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (indazoles and benzothiazoles), which act as ligands for the α7 nACh receptor subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.