869886-88-4

Basic information

• Product Name: 4-(5-chloro-2-isopropylaminopyridin-4-yl)-1-(toluene-4-sulfonyl)-1H-pyrrole-2-carboxylic acid methyl ester
• Synonyms: 4-(5-chloro-2-isopropylaminopyridin-4-yl)-1-(toluene-4-sulfonyl)-1H-pyrrole-2-carboxylic acid methyl ester
• CAS NO: 869886-88-4
• Molecular Weight: 447.942
• Mol File: 869886-88-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-(5-chloro-2-isopropylaminopyridin-4-yl)-1-(toluene-4-sulfonyl)-1H-pyrrole-2-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(5-chloro-2-isopropylaminopyridin-4-yl)-1-(toluene-4-sulfonyl)-1H-pyrrole-2-carboxylic acid methyl ester(869886-88-4)
• EPA Substance Registry System: 4-(5-chloro-2-isopropylaminopyridin-4-yl)-1-(toluene-4-sulfonyl)-1H-pyrrole-2-carboxylic acid methyl ester(869886-88-4)

Safety Data

• Hazardous Substances Data: 869886-88-4(Hazardous Substances Data)

Upstream product

• 40740-41-8 methyl 4-iodo-1H-pyrrole-2-carboxylic acid ester 
• 72652-33-6 4-iodo-2-(trichloroacetyl)pyrrole 
• 35302-72-8 pyrrol-2-yl trichloromethyl ketone 
• 869886-85-1 4-iodo-1-(toluene-4-sulfonyl)-1H-pyrrole-2-carboxylic acid methyl ester 
• 869886-87-3 5-chloro-4-iodo-N-isopropylpyridin-2-amine 
• 916177-00-9 (5-(methoxycarbonyl)-1-tosyl-1H-pyrrol-3-yl)boronic acid 
• 659731-48-3 5-chloro-2-fluoro-4-iodopyridine 

Downstream Products

• 869886-90-8 4-(5-chloro-2-isopropylaminopyridin-4-yl)-1H pyrrole-2-carboxylic acid 
• 869886-67-9 4-[5-chloro-2-[(1-methylethyl)amino]-4-pyridinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide 
• 1956366-10-1 4-(5-chloro-2-isopropylaminopyridin-4-yl)-1H-pyrrole-2-carboxylicacid[1-(3-chlorophenyl)-2-hydroxyethyl]amide hydrochloride 
• 1956366-10-1 4-(5-chloro-2-isopropylaminopyridin-4-yl)-1H-pyrrole-2-carboxylic acid [1-(3-chlorophenyl)-2-hydroxyethyl]amide hydrochloride 

Relevant articles and documents

ERK INHIBITOR AND USE THEREOF

Disclosed are a compound (as shown in formula I) as an extracellular signal-regulated kinase (ERK) inhibitor, a pharmaceutical composition thereof, a preparation method therefor, and use thereof in treating ERK-mediated diseases. Said compound plays a role by regulating a plurality of processes such as cell proliferation, apoptosis, migration and angiogenesis.

CRYSTALLINE C21H22C12N4O2 MALONATE

The present invention provides a malonate salt of a compound of formula (I), which is a crystalline salt. Also provided are pharmaceutical compositions that include the provided malonate salt and methods of using the provided crystalline forms and pharmaceutical compositions for the treatment of cancer.