869996-80-5Relevant articles and documents
Optimization of the in vitro and in vivo properties of a novel series of 2,4,5-trisubstituted imidazoles as potent cholecystokinin-2 (CCK2) antagonists
Buck, Ildiko M.,Black, James W.,Cooke, Tracey,Dunstone, David J.,Gaffen, John D.,Griffin, Eric P.,Harper, Elaine A.,Hull, Robert A. D.,Kalindjian, S. Barret,Lilley, Elliot J.,Linney, Ian D.,Low, Caroline M. R.,McDonald, Iain M.,Pether, Michael J.,Roberts, Sonia P.,Shankley, Nigel P.,Shaxted, Mark E.,Steel, Katherine I. M.,Sykes, David A.,Tozer, Matthew J.,Watt, Gillian F.,Walker, Martin K.,Wright, Laurence,Wright, Paul T.
, p. 6803 - 6812 (2005)
The systematic optimization of the structure of a novel 2,4,5-trisubstituted imidazole-based cholecystokinin-2 (CCK2) receptor antagonist afforded analogues with nanomolar receptor affinity. These compounds were now comparable in their potency
