870281-85-9

Basic information

• Product Name: (S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate
• Synonyms: (S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate(CAL101 N-2 step);(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate, [(1S)-1-(5-Fluoro-3,4-dihydro-4-oxo-3-phenyl-2-quinazolinyl)propyl]carbamic acid 1,1-dimethylethyl ester;tert-butyl (S)-[1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl]carbamate;(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate;idelalisib N-2;[(1S)-1-(5-Fluoro-3,4-dihydro-4-oxo-3-phenyl-2-quinazolinyl)propyl]carbamic acid 1,1-dimethylethyl ester
• CAS NO: 870281-85-9
• Molecular Formula: C₂₂H₂₄FN₃O₃
• Molecular Weight: 397.4426632
• EINECS: 1592732-453-0
• Mol File: 870281-85-9.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• Density: 1.21±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 11.39±0.46(Predicted)
• CAS DataBase Reference: (S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate(870281-85-9)
• EPA Substance Registry System: (S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate(870281-85-9)

Safety Data

• Hazardous Substances Data: 870281-85-9(Hazardous Substances Data)

Usage

Description

(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate is a complex organic compound with a unique molecular structure. It is characterized by a chiral center, denoted by the "S" configuration, and a tert-butyl group. The molecule also features a 5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl moiety, which is connected to a propyl chain through a carbamate linkage. (S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate is of interest in the field of medicinal chemistry due to its potential applications in drug discovery and development.

Uses

Used in Pharmaceutical Industry:
(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate is used as a reagent for the discovery of phosphoinositide 3-kinase (PI3K) b/d inhibitors. These inhibitors are of significant interest for the treatment of phosphatase and tensin homolog (PTEN) deficient tumors, as they can help regulate the PI3K/AKT/mTOR signaling pathway, which is often dysregulated in cancer cells. By targeting this pathway, (S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate contributes to the development of novel therapeutic agents for cancer treatment.

Upstream product

• 870281-84-8 (S)-[1-(2-fluoro-6-nitro-benzoy)phenylaminocarbonyl]propyl carbamic acid tert-butyl ester 
• 62-53-3 aniline 
• 870281-83-7 2-fluoro-6-nitro-N-phenyl-benzamide 
• 45121-22-0 Boc-D-Abu 
• 385-02-4 6-fluoro-2-nitrobenzoic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 78755-94-9 5-fluoro-2H-benzo[d][1,3]-oxazine-2,4(1H)-dione 
• 434-76-4 2-amino-6-fluorobenzoic acid 
• 34306-42-8 Boc-Abu 
• 1417456-04-2 2-amino-6-fluoro-N-phenyl-benzamide 
• 7304-32-7 2-fluoro-5-nitrobenzoic acid 

Downstream Products

• 870281-86-0 (S)-2-(1-((9H-purin-6-yl-2,8-d2)amino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one 
• 870281-82-6 5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one 

Relevant articles and documents

Construction of N-Boc-2-Alkylaminoquinazolin-4(3H)-Ones via a Three-Component, One-Pot Protocol Mediated by Copper(II) Chloride that Spares Enantiomeric Purity

Chiral 2-alkylquinazolinones are key synthetic intermediates, but their preparation in high optical purity is challenging. Thus, a multicomponent procedure integrating anthranilic acids, N-Boc-amino acids, and amines in the presence of methanesulfonyl chl

HETEROARYL DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSTION FOR PREVENTING OR TREATING DISEASES ASSOCIATED WITH PI3 KINASES, CONTAINING SAME AS ACTIVE INGREDIENT

The present invention relates to a heteroaryl derivative or a pharmaceutically acceptable salt thereof, a preparation method therefor, and a pharmaceutical composition for preventing or treating diseases associated with PI3 kinases, containing the same as an active ingredient. The heteroaryl derivative according to the present invention has an excellent effect of selectively inhibiting PI3 kinases, thereby being useful in preventing or treating PI3 kinase diseases such as: cancers, autoimmune diseases, and respiratory diseases.

A preparation method of generation of ralli department intermediates (by machine translation)

The invention discloses a method for the preparation of generation of ralli department, aniline, N - Boc - L - 2 - aminobutyric acid, DCC, triethylamine, 2 - fluoro - 5 - nitrophenyl chloride as the raw material, through the condensation reaction, the ami