87032-82-4

Basic information

• Product Name: 3-hydroxypyridine-4-carbonitrile
• Synonyms: 3-hydroxypyridine-4-carbonitrile;3-Hydroxyisonicotinonitrile;3-Hydroxypyridine-4-carbonitrile, 4-Cyano-3-hydroxypyridine;4-Cyano-3-hydroxypyridine
• CAS NO: 87032-82-4
• Molecular Formula: C6H4N2O
• Molecular Weight: 120.10876
• EINECS: 604-604-1
• Mol File: 87032-82-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 166 °C
• Boiling Point: 393.6±27.0 °C(Predicted)
• Appearance: /
• Density: 1.33±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 5.38±0.10(Predicted)
• CAS DataBase Reference: 3-hydroxypyridine-4-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxypyridine-4-carbonitrile(87032-82-4)
• EPA Substance Registry System: 3-hydroxypyridine-4-carbonitrile(87032-82-4)

Safety Data

• Hazardous Substances Data: 87032-82-4(Hazardous Substances Data)

Usage

General Description

3-Hydroxypyridine-4-carbonitrile is a chemical compound with the molecular formula C6H4N2O and a molecular weight of 124.11 g/mol. It is a pyridine derivative with a hydroxyl and a nitrile group attached to the 4th carbon atom. 3-hydroxypyridine-4-carbonitrile is used as a building block in the synthesis of pharmaceuticals and agrochemicals. It is also known to exhibit biological activities such as anti-inflammatory and analgesic properties. 3-Hydroxypyridine-4-carbonitrile has a wide range of applications in the pharmaceutical and chemical industries, making it a valuable intermediate compound in various organic synthesis processes.

Upstream product

• 15031-12-6 5-ethoxyoxazole 
• 107-13-1 acrylonitrile 
• 10128-73-1 3-hydroxyisonicotinamide 
• 878194-91-3 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-4-carbonitrile 
• 945989-08-2 3-(2-(trimethylsilyl)ethoxy)isonicotinonitrile 
• 14906-59-3 4-cyanopyridine N-oxide 
• 68325-15-5 3-chloro-isonicotinonitrile 

Downstream Products

• 927804-72-6 ethyl 3-aminofuro[2,3-c]pyridine-2-carboxylate 

Relevant articles and documents

2-AMINOPYRIDINE DERIVATIVES AS GLUCOKINASE ACTIVATORS

Provided are compounds having the Formula (I) or salts thereof, wherein: L is O, S, SO, SO2, CHOH, C(O), or CH2; D2 is CR12 or N; R2 is aryl, heteroaryl, saturated or partially unsaturated cycloalkyl, or saturated or partially unsaturated heterocyclyl (optionally substituted with oxo), wherein said aryl, heteroaryl, cycloalkyl and heterocyclyl are monocyclic or bicyclic and are further optionally substituted with one or more groups independently selected from C1-C6 alkyl, F, Cl, Br, I, CF3, CN, OR6, C(=O)R6, C(=O)OR6, O(CH2)nC(=O)OR6, C(=O)NR6R7, NO2 and (1-6C alkyl)OR6; R3 is H, Br, OR6, SR6, C(O)OR6, C(O)NR6R7, C(O)R6, heteroaryl, or C1-C6 alkyl substituted with one or more groups independently selected from Vn-aryl, Vn-OR6, Vn- C(=O)OR6 and Vn-NR6R7; R11 is H or Cl; and R13 is N-(1 -6C alkanoyl)piperidin-4-yl; that are useful in the treatment and/or prevention of diseases mediated by deficient levels of glucokinase activity, such as diabetes mellitus. Also provided are methods of treating or preventing diseases and disorders characterized by underactivity of glucokinase or which can be treated by activating glucokinase.

Straightforward access to ethyl 3-aminofuropyridine-2-carboxylates from 1-chloro-2-cyano- or 1-hydroxy-2-cyano-substituted pyridines

The conditions of the synthesis of the four regioisomers of ethyl 3-aminofuropyridine-2-carboxylate are described and discussed in detail. The starting materials are either 1-chloro-2-cyanopyridines or 1-cyano-2- hydroxypyridines. Georg Thieme Verlag Stuttgart.

Oxazoles in Diels-Alder Reactions. Transformation of The Adducts to Either Pyridines or Pyrroles

The cycloadducts between acrylic acid or acrylonitrile and 5-ethoxyoxazoles are converted as formed to 3-hydroxypyridines.The Diels-Alder adducts from ethyl acrylate, or methyl or phenyl vinyl ketone can be isolated.In ethanolic HCl the adducts are transformed into 3-hydroxypyridines; in aqueous HCl the products are acylpyrrole analogues.A 4-substituent in the oxazole affects the reaction. 4-Methyl-5-ethoxyoxazole reacts much faster than its 5-ethylthio analogue.