870653-45-5

Basic information

• Product Name: 5-(4-PHENOXYBUTOXY)PSORALEN
• Synonyms: 5-(4-PHENOXYBUTOXY)PSORALEN;PAP-1;7H-Furo[3,2-g][1]benzopyran-7-one, 4-(4-phenoxybutoxy)-;4-(4-Phenoxybutoxy)-7H-furo[3,2-g][1]benzopyran-7-one;2-g][1]benzopyran-7-one;4-(4-phenoxybutoxy)-;7H-Furo[3;PAP-1,5-(4-Phenoxybutoxy)psoralen
• CAS NO: 870653-45-5
• Molecular Formula: C₂₁H₁₈O₅
• Molecular Weight: 350.36
• EINECS: 200-258-5
• Product Categories: API intermediates
• Mol File: 870653-45-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 555.8 °C at 760 mmHg
• Flash Point: 289.9 °C
• Appearance: white/solid
• Density: 1.269
• Vapor Pressure: 2.17E-12mmHg at 25°C
• Refractive Index: 1.618
• Storage Temp.: 2-8°C
• Solubility: DMSO: 9 mg/mL
• CAS DataBase Reference: 5-(4-PHENOXYBUTOXY)PSORALEN(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-PHENOXYBUTOXY)PSORALEN(870653-45-5)
• EPA Substance Registry System: 5-(4-PHENOXYBUTOXY)PSORALEN(870653-45-5)

Safety Data

• Statements: 42/43
• Safety Statements: 22-36/37-45
• WGK Germany: 3
• Hazardous Substances Data: 870653-45-5(Hazardous Substances Data)

Usage

Description

5-(4-Phenoxybutoxy)psoralen, with the chemical abstracts service number 870653-45-5, is a selective small molecule that functions as a blocker of the lymphocyte K+ channel Kv1.3. This characteristic makes it a significant compound in the field of immunology and medicine, particularly for modulating immune responses.

Uses

Used in Pharmaceutical Industry:
5-(4-Phenoxybutoxy)psoralen is utilized as an immunosuppressive agent for the management of autoimmune diseases. Its application is primarily due to its ability to suppress effector memory T cells, which play a crucial role in the pathogenesis of various autoimmune conditions.
Used in Autoimmune Disease Management:
In the context of autoimmune diseases, 5-(4-Phenoxybutoxy)psoralen is used as a therapeutic intervention to control the activity of effector memory T cells. By doing so, it helps in mitigating the symptoms and progression of these diseases, offering a targeted approach to treatment.

Biochem/physiol Actions

Selective inhibitor of Kv1.3, voltage-gated K+ channel. PAP-1 (EC50=2 nM) potently inhibits human T effector memory cell proliferation and delayed hypersensitivity. Effective orally or intraperitoneally. 5-(4-Phenoxybutoxy)psoralen has 23-fold selectivity for Kv1.3 over Kv1.5, and 33-125-fold selectivity over other Kv1 family channels.

InChI:InChI=1/C21H18O5/c22-20-9-8-16-19(26-20)14-18-17(10-13-24-18)21(16)25-12-5-4-11-23-15-6-2-1-3-7-15/h1-3,6-10,13-14H,4-5,11-12H2

Upstream product

• 486-60-2 bergaptol 
• 1200-03-9 4-bromophenyl butyl ether 
• 484-20-8 bergapten 
• 139-02-6 sodium phenoxide 

Downstream Products

• 1158850-20-4 4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromene-7-thione 

Relevant articles and documents

5-phenoxyalkoxypsoralens and methods for selective inhibition of the voltage gated Kv1.3 potassium channel

Compositions of matter comprising 5-phenoxyalkoxypsoralen compounds and their method of synthesis and use. The compounds are useable to treat diseases or disorders in human or animal subjects, including autoimmune diseases. The compounds inhibit potassium