870997-87-8 Usage
Description
N-Methyl-2-aminopyridine-3-carboxamide is an organic compound that serves as a key intermediate in the synthesis of triazolopyrazine derivatives and analogs. It is characterized by its unique molecular structure, which includes a pyridine ring, an amide group, and a methyl group attached to the nitrogen atom. N-Methyl-2-aminopyridine-3-carboxamide plays a crucial role in the development of pharmaceuticals targeting specific kinase activities.
Uses
Used in Pharmaceutical Industry:
N-Methyl-2-aminopyridine-3-carboxamide is used as a chemical intermediate for the preparation of triazolopyrazine derivatives and analogs. These compounds are of significant interest due to their potential as c-MET kinase activity inhibitors.
As c-MET Kinase Inhibitors:
N-Methyl-2-aminopyridine-3-carboxamide is utilized in the development of c-MET kinase inhibitors, which are important for the treatment of various diseases, including cancer. The c-MET kinase is a receptor tyrosine kinase involved in cell proliferation, survival, and migration. Inhibition of this kinase can lead to the suppression of tumor growth and metastasis, making it a promising target for therapeutic intervention.
In the synthesis of triazolopyrazine derivatives and analogs, N-Methyl-2-aminopyridine-3-carboxamide serves as a building block, providing the necessary structural features for the formation of biologically active compounds. These derivatives have the potential to modulate c-MET kinase activity, thereby offering new treatment options for patients with cancer and other diseases where c-MET kinase plays a critical role.
Check Digit Verification of cas no
The CAS Registry Mumber 870997-87-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,0,9,9 and 7 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 870997-87:
(8*8)+(7*7)+(6*0)+(5*9)+(4*9)+(3*7)+(2*8)+(1*7)=238
238 % 10 = 8
So 870997-87-8 is a valid CAS Registry Number.
InChI:InChI=1/C7H9N3O/c1-9-7(11)5-3-2-4-10-6(5)8/h2-4H,1H3,(H2,8,10)(H,9,11)
870997-87-8Relevant articles and documents
BENZOXAZINONE DERIVATIVES FOR THE TREATMENT OF GLYTL MEDIATED DISORDERS
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Page/Page column 91; 92, (2011/02/24)
The present invention relates to benzoxazinone derivatives, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in treating disorders mediated by GlyT1, including neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder.
QUINAZOLINE DERIVATIVE
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Page/Page column 53, (2010/11/25)
This invention provides a compound or its pharmaceutically-acceptable salt of formula (I) wherein R 1 represents a lower alkyl group et al; R 2 and R 3 are same and different and represents hydrogen atm et al; R 4 represents the substituent of the formula (II) et al; X 1 represents NH, O or S; Y represents N or C; Ar is a divalent substituent derived from aryl et al, by removing two hydrogen atoms therefrom; the ring A represents a 5- or 6-membered heteroaryl group; this compounds has a histamine-H3 receptor antagonistic effect or a histamine-H3 receptor inverse-agonistic effect and is useful for preventive or remedy of metabolic system diseases, circulatory system diseases or nervous system diseases.
Syntheses and diuretic activity of 1,2-dihydro-2-(3-pyridyl)-3H-pyrido[2,3-d]pyrimidin-4-one and related compounds
Parish Jr.,Gilliom,Purcell,Browne,Spirk,White
, p. 98 - 102 (2007/10/02)
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