871-76-1Relevant articles and documents
Powerful Bipodal Anion Transporters Based on Scaffolds That Contain Different Chalcogens
Lang, Chao,Zhang, Xin,Luo, Quan,Dong, Zeyuan,Xu, Jiayun,Liu, Junqiu
, p. 6458 - 6465 (2015/10/19)
A new family of bipodal anion transporters based on chalcogen-containing scaffolds has been designed and synthesized. Though structurally related to the well-studied tripodal anionophores, these molecules are simpler with only two anion-binding sites. However, the activities remain high. Anion transport could be facilitated by the new transporter at an exceptionally low loading of transporter/lipid ratio of 1:500000. This impressive efficiency is comparable with the most active one from the tren-based tripodal series. To investigate influences from different scaffolds and substituent groups, lipophilicity, anion-binding property, and transport activity of each molecule were studied. It was found that the bridge atom has a major impact on transport activities mainly as a result of anion-binding differences. The results also suggest that chalcogen can act as a key structural modulator to develop highly effective anion transporters and optimize their activities. Anion transporters based on chalcogen-containing scaffolds have been designed and synthesized. Their lipophilicities, anion binding properties, and transport activities were investigated in detail. The results suggest that chalcogen can act as a key structural modulator to develop highly effective anion transporters and optimize their activities.
Straightforward approach to efficient oxidative DNA cleaving agents based on Cu(ii) complexes of heterosubstituted cyclens
Hormann, Jan,Perera, Chrischani,Deibel, Naina,Lentz, Dieter,Sarkar, Biprajit,Kulak, Nora
supporting information, p. 4357 - 4360 (2013/04/24)
The Cu(ii) complexes of cyclen and two of its heterosubstituted analogues were shown to be efficient oxidative DNA cleavers. The reactivity strongly depends on the heteroatom inserted into the macrocycle (O > S > N). The Royal Society of Chemistry 2013.
A mild and highly convenient chemoselective alkylation of thiols using Cs2CO3-TBAI
Salvatore, Ralph Nicholas,Smith, Robert A.,Nischwitz, Adam K.,Gavin, Terrence
, p. 8931 - 8935 (2007/10/03)
A mild and improved method for the synthesis of thioethers has been developed. In the presence of cesium carbonate, tetrabutylammonium iodide, and DMF, various alkyl and aryl thiols underwent S-alkylation to afford structurally diverse sulfides in high yield. Unprotected mercaptoalcohols and thioamines reacted chemoselectively at the sulfur moiety exclusively. An example of a one-pot, solid-phase synthesis of a thioether is also described.