87121-58-2

Basic information

• Product Name: 2-(ethylamino)isonicotinonitrile
• Synonyms: 2-(ethylamino)isonicotinonitrile;2-(Ethylamino)-4-pyridinecarbonitrile;2-(ethylamino)pyridine-4-carbonitrile
• CAS NO: 87121-58-2
• Molecular Formula: C₈H₉N₃
• Molecular Weight: 147
• Mol File: 87121-58-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 276℃
• Flash Point: 121℃
• Appearance: /
• Density: 1.10
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(ethylamino)isonicotinonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(ethylamino)isonicotinonitrile(87121-58-2)
• EPA Substance Registry System: 2-(ethylamino)isonicotinonitrile(87121-58-2)

Safety Data

• Hazardous Substances Data: 87121-58-2(Hazardous Substances Data)

Usage

General Description

2-(ethylamino)isonicotinonitrile, also known as ethylaminoisonicotinonitrile, is a chemical compound with the molecular formula C9H10N4. It is a pale yellow solid with a melting point of 173-179°C. 2-(ethylamino)isonicotinonitrile is commonly used in organic synthesis as a building block for the preparation of complex organic molecules. It can be used as a reactant in the production of pharmaceuticals, agrochemicals, and other fine chemicals. It is also a key intermediate in the synthesis of various heterocyclic compounds and has potential applications in the development of new drugs and materials. Overall, 2-(ethylamino)isonicotinonitrile is a versatile chemical with multiple industrial and research applications.

Upstream product

• 33252-30-1 2-chloro-4-pyridinenitrile 
• 75-04-7 ethylamine 

Relevant articles and documents

Diarylthiazole: An antimycobacterial scaffold potentially targeting PrrB-PrrA two-component system

Diarylthiazole (DAT), a hit from diversity screening, was found to have potent antimycobacterial activity against Mycobacterium tuberculosis (Mtb). In a systematic medicinal chemistry exploration, we demonstrated chemical opportunities to optimize the potency and physicochemical properties. The effort led to more than 10 compounds with submicromolar MICs and desirable physicochemical properties. The potent antimycobacterial activity, in conjunction with low molecular weight, made the series an attractive lead (antibacterial ligand efficiency (ALE) >0.4). The series exhibited excellent bactericidal activity and was active against drug-sensitive and resistant Mtb. Mutational analysis showed that mutations in prrB impart resistance to DAT compounds but not to reference drugs tested. The sensor kinase PrrB belongs to the PrrBA two component system and is potentially the target for DAT. PrrBA is a conserved, essential regulatory mechanism in Mtb and has been shown to have a role in virulence and metabolic adaptation to stress. Hence, DATs provide an opportunity to understand a completely new target system for antimycobacterial drug discovery.

The synthesis of 2-amino-4-(4-imidazolyl)pyridines

A general synthetic scheme for the preparation of 2-amino-4-(4-imidazolyl)pyridines, potential histamine H2 antagonists, is described. The synthesis is based on the Neber rearrangement of 1-(4-pyridyl)-l-alkanone oxime O-tosylates to the appropriate α-aminoketones or α-aminoketals, which are then converted to the corresponding imidazoles. The reaction of Grignard reagents with 2-chloroisonicotinonitrile, as well as nucleophilic displacement of chloride by amines on 2-chloroisonicotinonitrile and derivatives, are discussed in relation to the preparation of the ketone intermediates.