87121-59-3

Basic information

• Product Name: 2-Chloro-N,N'-diethyl-isonicotinamidine
• CAS NO: 87121-59-3
• Molecular Weight: 211.694
• Mol File: 87121-59-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Chloro-N,N'-diethyl-isonicotinamidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-N,N'-diethyl-isonicotinamidine(87121-59-3)
• EPA Substance Registry System: 2-Chloro-N,N'-diethyl-isonicotinamidine(87121-59-3)

Safety Data

• Hazardous Substances Data: 87121-59-3(Hazardous Substances Data)

Upstream product

• 33252-30-1 2-chloro-4-pyridinenitrile 
• 75-04-7 ethylamine 

Relevant articles and documents

The synthesis of 2-amino-4-(4-imidazolyl)pyridines

A general synthetic scheme for the preparation of 2-amino-4-(4-imidazolyl)pyridines, potential histamine H2 antagonists, is described. The synthesis is based on the Neber rearrangement of 1-(4-pyridyl)-l-alkanone oxime O-tosylates to the appropriate α-aminoketones or α-aminoketals, which are then converted to the corresponding imidazoles. The reaction of Grignard reagents with 2-chloroisonicotinonitrile, as well as nucleophilic displacement of chloride by amines on 2-chloroisonicotinonitrile and derivatives, are discussed in relation to the preparation of the ketone intermediates.