871343-71-4

Basic information

• Product Name: C₁₅H₁₄Cl₂N₄OS
• Synonyms: C₁₅H₁₄Cl₂N₄OS
• CAS NO: 871343-71-4
• Molecular Weight: 369.274
• Mol File: 871343-71-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₅H₁₄Cl₂N₄OS(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₁₄Cl₂N₄OS(871343-71-4)
• EPA Substance Registry System: C₁₅H₁₄Cl₂N₄OS(871343-71-4)

Safety Data

• Hazardous Substances Data: 871343-71-4(Hazardous Substances Data)

Upstream product

• 22059-22-9 N-hydroxyacetamidine 
• 112366-39-9 3-[1-(3,4-dichloro-phenyl)-propyl]-2-mercapto-3H-imidazole-4-carboxylic acid methyl ester 

Relevant articles and documents

MERCAPTOIMIDAZOLES AS CCR2 RECEPTOR ANTAGONISTS

The present invention relates to a compound of formula (I), a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine or a stereochemically isomeric form thereof, wherein R1 represents hydrogen, C1-66alkyl, C3-7cycloalkyl, C1-66alkylo xyC1 -6alkyl, di(C1-6alkyl)aminoC1-6alkyl, aryl or heteroaryl; each R2 independently represents halo, C1-6alkyl, C1-6alkyloxy, C1-6alkylthio, polyhaloC1-6alkyl, polyhaloC1-6alkyloxy, cyano, aminocarbonyl, amino, mono-or di(C1-4alkyl)amino, nitro, aryl or aryloxy; R3 represents hydrogen, cyano, optionally subst ituted C1-66alkyl, C(=O)-O-R5, C(=O)-NR6aR6b, C(=S)-NR6aR6b, S(=O)2-NR6aR6b or C(=O)-R7; R4 represents hydrogen or C1-6alkyl; n is 1, 2, 3, 4 or 5; Z represents a cyclic ring system. The invention also relates to processes for preparing the compounds of formula (I), their use as CCR2 antagonists and pharmaceutical compositions comprising them.