872002-72-7

Basic information

• Product Name: Quinoxaline, 6-[[4-[2-[4-(1,1-dimethylethyl)phenyl]-1H-benzimidazol-7-yl]-1-piperazinyl]methyl]-
• CAS NO: 872002-72-7
• Molecular Weight: 476.624
• Mol File: 872002-72-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Quinoxaline, 6-[[4-[2-[4-(1,1-dimethylethyl)phenyl]-1H-benzimidazol-7-yl]-1-piperazinyl]methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Quinoxaline, 6-[[4-[2-[4-(1,1-dimethylethyl)phenyl]-1H-benzimidazol-7-yl]-1-piperazinyl]methyl]-(872002-72-7)
• EPA Substance Registry System: Quinoxaline, 6-[[4-[2-[4-(1,1-dimethylethyl)phenyl]-1H-benzimidazol-7-yl]-1-piperazinyl]methyl]-(872002-72-7)

Safety Data

• Hazardous Substances Data: 872002-72-7(Hazardous Substances Data)

Upstream product

• 53967-21-8 6-bromomethyl-quinoxaline 
• 131543-46-9 Glyoxal 
• 874279-45-5 4-((4-(2-(4-tert-butylphenyl)-1H-benzo[d]imidazol-4-yl)piperazin-1-yl)methyl)benzene-1,2-diamine 

Relevant articles and documents

Discovery of 6-({4-[2-(4-tert-Butylphenyl)-1H-benzimidazol-4-yl]piperazin- 1-yl}methyl)quinoxaline(WAY-207024): An orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R)

A potent, highly insoluble, GnRH antagonist with a 2-phenyl-4- piperazinylbenzimidazole template and a quinoxaline-2,3-dione pharmacophore was modified to maintain GnRH antagonist activity and improve in vitro pharmaceutical properties. Structural changes

Processes for preparing gonadotropin releasing hormone receptor antagonists

The present invention relates to methods of making Gonadotropin Releasing Hormone (“GnRH”) (also known as Leutinizing Hormone Releasing Hormone) receptor antagonists.