872041-85-5 Usage
Description
Boronic acid, B-(5-chloro-3-pyridinyl)-, is an organic compound that features a boron atom bonded to a pyridine ring with a chloro substituent. It is known for its unique chemical properties and reactivity, making it a versatile building block in organic synthesis and medicinal chemistry.
Uses
Used in Pharmaceutical Industry:
Boronic acid, B-(5-chloro-3-pyridinyl)-, is used as an intermediate in the synthesis of various pharmaceutical compounds for different therapeutic applications.
1. Positron Emission Tomography (PET) Radioligand Synthesis:
Boronic acid, B-(5-chloro-3-pyridinyl)-, is used as a key intermediate in the preparation of [11C]MK-1064, a PET radioligand applicable in orexin-2 receptor imaging. This helps in visualizing the distribution and density of orexin-2 receptors in the body, aiding in the diagnosis and monitoring of related neurological disorders.
2. Orexin 2 Receptor Antagonist Synthesis:
It serves as an intermediate in the synthesis of orexin 2 receptor antagonist (2-SORA) MK-1064, which has potential applications in the treatment of various sleep disorders and other conditions related to the orexin system.
3. Prostaglandin E Synthase-1 Inhibitors:
Boronic acid, B-(5-chloro-3-pyridinyl)-, is used in the preparation of pyridyl-cycloalkyl derived microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors. These inhibitors can modulate the production of prostaglandins, which play a crucial role in inflammation and pain, offering potential therapeutic benefits in treating inflammatory conditions.
4. ATAD2 Bromodomain Inhibitors:
It is also utilized in the synthesis of ATAD2 bromodomain inhibitors, which target a specific protein-protein interaction involved in cellular processes such as gene transcription and cell cycle regulation. These inhibitors have potential applications in the development of anticancer drugs, as they can disrupt the function of proteins driving tumor growth and progression.
Check Digit Verification of cas no
The CAS Registry Mumber 872041-85-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,2,0,4 and 1 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 872041-85:
(8*8)+(7*7)+(6*2)+(5*0)+(4*4)+(3*1)+(2*8)+(1*5)=165
165 % 10 = 5
So 872041-85-5 is a valid CAS Registry Number.
InChI:InChI=1/C5H5BClNO2/c7-5-1-4(6(9)10)2-8-3-5/h1-3,9-10H