872088-11-4 Usage
Preparation
Obtained by reaction of 3,5-dichlorophenylmagnesium bromide with 5-chloro-2-methoxybenzoyl chloride in the presence of bis[2-(N,N-dimethylamino)ethyl] ether in THF at ?5 to 0° (85%).
Check Digit Verification of cas no
The CAS Registry Mumber 872088-11-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,2,0,8 and 8 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 872088-11:
(8*8)+(7*7)+(6*2)+(5*0)+(4*8)+(3*8)+(2*1)+(1*1)=184
184 % 10 = 4
So 872088-11-4 is a valid CAS Registry Number.
InChI:InChI=1/C14H9Cl3O2/c1-19-13-3-2-9(15)7-12(13)14(18)8-4-10(16)6-11(17)5-8/h2-7H,1H3
872088-11-4Relevant articles and documents
Addition of Grignard reagents to aryl acid chlorides: An efficient synthesis of aryl ketones
Wang, Xiao-Jun,Zhang, Li,Sun, Xiufeng,Xu, Yibo,Krishnamurthy, Dhileepkumar,Senanayake, Chris H.
, p. 5593 - 5595 (2005)
(Chemical Equation Presented) Direct addition of Grignard reagents to acid chlorides in the presence of bis[2-(N,N-dimethylamino)ethyl] ether proceeds selectively to provide aryl ketones in high yields. A possible tridentate interaction between Grignard reagents and bis[2-(N,N-dimethylamino)ethyl] ether moderates the reactivity of Grignard reagents, preventing the newly formed ketones from nucleophilic addition by Grignard reagents.
