872254-19-8Relevant articles and documents
ISATIN ANALOGUES AND USES THEREFOR
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Page/Page column 10, (2009/04/24)
Novel isatin analogues, including isatin analogues comprising Michael Acceptors (IMAs) are disclosed. Further disclosed are methods of synthesis of the isatin analogues, and uses of the analogues, including inhibition of caspase-3 and caspase-7, and in vi
Isatin sulfonamide analogs containing a Michael addition acceptor: A new class of caspase 3/7 inhibitors
Chu, Wenhua,Rothfuss, Justin,D'Avignon, André,Zeng, Chenbo,Zhou, Dong,Hotchkiss, Richard S.,Mach, Robert H.
, p. 3751 - 3755 (2008/02/10)
A series of isatin sulfonamide analogs having a Michael acceptor were prepared and their potencies for inhibiting caspase-1, -3, -6, -7, and -8 were evaluated. These compounds have nanomolar potency for inhibiting the executioner caspases, caspase-3 and c
5-PYRROLIDINYLSULFONYL ISATIN DERIVATIVES
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Page/Page column 30-31; 40, (2008/06/13)
The present invention relates to novel 5-pyrrolidinylsulfonyl isatin derivatives, non-peptidyl Caspase binding Radioligands (CbRs) and CbR-transporter conjugates derived from said isatin derivatives, diagnostic compositions comprising said compounds of th