872269-68-6Relevant articles and documents
Catalytic enantioselective reformatsky reaction with ortho-substituted diarylketones
Fernandez-Ibanez, M. Angeles,Macia, Beatriz,Minnaard, Adriaan J.,Feringa, Ben L.
supporting information; experimental part, p. 4041 - 4044 (2009/05/27)
(Chemical Equation Presented) The catalytic enantioselective Reformatsky reaction with ortho-substituted diarylketones with good enantioselectivities and moderate to good yields is reported. A readily available BINOL derivative is used as a chiral catalyst, and the reactions are performed with ethyl iodoacetate as a nucleophile and Me2Zn as the zinc source. The presence of air was found to be crucial to achieve an effective C-C bond formation pointing to a radical mechanism.