872511-30-3 Usage
Description
6-Chloro-N-ethylpyrimidin-4-amine is an organic compound that serves as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals. It is characterized by the presence of a chlorine atom at the 6-position and an ethylamine group attached to the 4-position of the pyrimidine ring. This unique structure endows it with versatile reactivity and potential applications in the development of therapeutic agents.
Uses
Used in Pharmaceutical Industry:
6-Chloro-N-ethylpyrimidin-4-amine is used as a reactant in the preparation of aryl-pyrimidinyl ureas, which are potential fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitors and antitumor agents. FGFR inhibitors are of significant interest in the development of targeted cancer therapies, as they can help regulate cell growth and division, thereby inhibiting tumor progression.
In the synthesis of aryl-pyrimidinyl ureas, 6-Chloro-N-ethylpyrimidin-4-amine can be coupled with appropriate aryl isocyanates or isothiocyanates to form the desired urea derivatives. These compounds can then be further optimized and evaluated for their inhibitory activity against FGFR tyrosine kinases, which play a crucial role in various cellular processes, including cell proliferation, differentiation, and migration.
The development of FGFR inhibitors has shown promise in the treatment of various cancers, such as bladder, breast, lung, and gastric cancers, as well as certain types of leukemia. By targeting the FGFR pathway, these inhibitors can potentially disrupt the signaling cascades that drive tumor growth and metastasis, offering a novel therapeutic strategy for cancer patients.
Furthermore, 6-Chloro-N-ethylpyrimidin-4-amine may also find applications in other areas of medicinal chemistry, such as the synthesis of antiviral, antibacterial, and anti-inflammatory agents, due to its versatile reactivity and potential for structural modifications. Its use in the development of new drugs and therapeutic agents highlights the importance of this compound in the pharmaceutical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 872511-30-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,2,5,1 and 1 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 872511-30:
(8*8)+(7*7)+(6*2)+(5*5)+(4*1)+(3*1)+(2*3)+(1*0)=163
163 % 10 = 3
So 872511-30-3 is a valid CAS Registry Number.
InChI:InChI=1/C6H8ClN3/c1-2-8-6-3-5(7)9-4-10-6/h3-4H,2H2,1H3,(H,8,9,10)
872511-30-3Relevant articles and documents
ANTIVIRAL COMPOUNDS
-
Paragraph 90-94; 129-132, (2020/11/12)
The invention is provides novel antiviral compounds, as well as derivatives thereof. The compounds of the invention are preferably formulated as pharmaceuticals. The invention provides the compounds for use in the prevention and treatment of infectious diseases, in particular viral diseases. In some aspects the invention is based on the antiviral activity of the provided compounds against the Chikungunya virus, and hence, their application in the treatment or prevention of any physiological manifestation of such viral infection.
NEW TRPA1 ANTAGONISTS
-
Page/Page column 62; 63; 129, (2017/08/01)
The present invention relates to compounds of Formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by TRPA1 channel inhibition or antagonism.
Chemoselective reactions of 4,6-dichloro-2-(methylsulfonyl)pyrimidine and related electrophiles with amines
Baiazitov, Ramil,Du, Wu,Lee, Chang-Sun,Hwang, Seongwoo,Almstead, Neil G.,Moon, Young-Choon
, p. 1764 - 1784 (2013/07/26)
Chemoselective SNAr reactions of 4,6-dichloro-2-(methylsulfonyl) pyrimidine and several related electrophiles with amines and their derivatives are described. In the presence of weak bases anilines and secondary aliphatic amines selectively displace the chloride group. Deprotonated anilines and their carbonyl derivatives displace the sulfone group. Sterically and electronically unbiased primary aliphatic amines selectively displace the sulfone group in 4,6-dichloro-2-(methylsulfonyl)pyrimidine; however, their reactions with other electrophiles generally are less selective. Steric-driven selectivity explanation was proposed. Georg Thieme Verlag Stuttgart. New York.
