872516-87-5Relevant articles and documents
FUSED RING PYRIMIDINE COMPOUND, INTERMEDIATE, AND PREPARATION METHOD, COMPOSITION AND USE THEREOF
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Paragraph 0204-0205, (2018/08/12)
Disclosed area fused ring pyrimidine compound, and an intermediate, a preparation method, a composition and a use thereof. The fused ring pyrimidine compound is a compound as shown in formula I, a tautomer, an enantiomer, a diastereoisomer, a pharmaceutically acceptable salt, a metabolite, a metabolic precursor or a prodrug thereof, wherein the above-mentioned compound is used for the preparation of a medicine for preventing, remitting or treating one or more of immune system diseases, autoimmune diseases, cell proliferative diseases, allergic disorders and cardiovascular diseases, and the compound has a strong inhibitory effect on the Janues kinase, FGFR kinase, FLT3 kinase and Src family kinase.
Synthesis of macrocyclic bisbibenzyl derivatives and their anticancer effects as anti-tubulin agents
Jiang, Juan,Sun, Bin,Wang, Yan-Yan,Cui, Min,Zhang, Li,Cui, Chang-Zhi,Wang, Yan-Feng,Liu, Xi-Gong,Lou, Hong-Xiang
, p. 2382 - 2391 (2012/05/05)
Based on the core skeleton of the total synthesized bisbibenzyl marchantin C, riccardin D and plagiochin E, a series of brominated and aminomethylated derivatives of above three bisbibenzyls have been synthesized and their cytotoxic activity against KB, M
Ring strain and total syntheses of modified macrocycles of the isoplagiochin type
Speicher, Andreas,Backes, Timo,Hesidens, Kerstin,Kolz, Juergen
supporting information; experimental part, (2010/04/22)
Macrocycles of the bisbibenzyl-type are natural products that are found exclusively in bryophytes (liverworts). The molecular framework of the subtype "isoplagiochin" is of substantial structural interest because of the chirality of the entire molecule, w
