873-41-6Relevant articles and documents
Discovery of 1,2,4-triazine-based derivatives as novel neddylation inhibitors and anticancer activity studies against gastric cancer MGC-803 cells
Song, Jian,Cui, Xin-Xin,Wu, Bo-Wen,Li, Dong,Wang, Sheng-Hui,Shi, Lei,Zhu, Ting,Zhang, Yan-Bing,Zhang, Sai-Yang
supporting information, (2019/11/28)
Neddylation modification is often over-expressed in a variety of human tumor cells. Therefore, targeting neddylation pathway may represent a potential approach to the treatment of human tumors. Herein, we describe the discovery of a hit scaffold from our
HIV INHIBITING 1,2,4-TRIAZIN-6-ONE DERIVATIVES
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Page/Page column 62-63, (2008/06/13)
The present invention relates to HIV replication inhibitors of formula (I) a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine or a stereochemically isomeric form thereof, wherein ring A and ring B represent phenyl, pyridyl, pyridaz
Heterocyclic Polyfluoro-compounds. Part 39. Preparation and some Nucleophilic Substitution Reactions of Trifluoro-1,2,4-triazine
Barlow, Michael G.,Haszeldine, Robert N.,Simon, Charles,Simpkin, David J.,Ziervogel, Gerda
, p. 1251 - 1254 (2007/10/02)
Fluorination of trichloro-1,2,4-triazine over potassium fluoride at 450 deg C in a flow system yields trifluoro-(91percent) and 6-chloro-3,5-difluoro-1,2,4-triazine (5percent).The trifluorotriazine yields a dimer with time, which reverts to the monomer wi