874124-85-3Relevant articles and documents
Novel, sulfonamide linked inhibitors of the hepatitis C virus NS3 protease
Kirschberg, Thorsten A.,Squires, Neil H.,Yang, Huiling,Corsa, Amoreena C.,Tian, Yang,Tirunagari, Neeraj,Sheng, X. Christopher,Kim, Choung U.
, p. 969 - 972 (2014/02/14)
A sulfonamide replacement of the P2-P3 amide bond in the context of macrocyclic HCV NS3 protease inhibitors was investigated. These analogs displayed good inhibitory potency in the absence of any P3 capping group. The synthesis and preliminary SAR are des