874770-90-8

Basic information

• Product Name: 2-tert-butoxycarbonylamino-succinic acid 1-tert-butyl ester 4-[6-methoxy-2-(4-methoxy-phenyl)-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl] ester
• Synonyms: 2-tert-butoxycarbonylamino-succinic acid 1-tert-butyl ester 4-[6-methoxy-2-(4-methoxy-phenyl)-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl] ester
• CAS NO: 874770-90-8
• Molecular Weight: 553.607
• Mol File: 874770-90-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-tert-butoxycarbonylamino-succinic acid 1-tert-butyl ester 4-[6-methoxy-2-(4-methoxy-phenyl)-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl] ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-tert-butoxycarbonylamino-succinic acid 1-tert-butyl ester 4-[6-methoxy-2-(4-methoxy-phenyl)-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl] ester(874770-90-8)
• EPA Substance Registry System: 2-tert-butoxycarbonylamino-succinic acid 1-tert-butyl ester 4-[6-methoxy-2-(4-methoxy-phenyl)-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl] ester(874770-90-8)

Safety Data

• Hazardous Substances Data: 874770-90-8(Hazardous Substances Data)

Upstream product

• 532-20-7 D-Ribose 
• 1824-96-0 methyl ribofuranoside 
• 874770-89-5 [6-methoxy-2-(4-methoxyphenyl)tetrahydrofuro[3,4-d][1,3]-dioxol-4-yl]methanol 
• 34582-32-6 N-tert-butoxycarbonyl aspartic acid tert-butyl ester 

Relevant articles and documents

Investigation of the Yamaguchi esterification mechanism. Synthesis of a Lux-S enzyme inhibitor using an improved esterification method

(Chemical Equation Presented) A one-pot procedure for the regioselective synthesis of aliphatic esters is described. This was a result of a study on mixed aliphatic-aromatic anhydrides. The data suggest that during the Yamaguchi esterification reaction, a symmetric aliphatic anhydride is produced in situ, which upon reaction with an alcohol yields the ester. We confirmed that benzoyl chloride could be used instead of the sterically hindered Yamaguchi acid chloride. This method was successfully applied in the synthesis of Lux-S aspartic acid inhibitor.