874819-71-3

Basic information

• Product Name: N-(2-Nitrophenyl)phosphoric TriaMide
• Synonyms: (2-Nitrophenyl)phosphoric TriaMide;N-(2-Nitrophenyl)phosphoric TriaMide;N-diaminophosphoryl-2-nitroaniline
• CAS NO: 874819-71-3
• Molecular Formula: C6H9N4O3P
• Molecular Weight: 216.134421
• Product Categories: Amines;Aromatics;Phosphorylating and Phosphitylating Agents
• Mol File: 874819-71-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 416.5±47.0 °C(Predicted)
• Appearance: /
• Density: 1.592±0.06 g/cm3(Predicted)
• Vapor Pressure: 0Pa at 20℃
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 3.07±0.70(Predicted)
• Water Solubility: 1.394g/L at 20℃
• CAS DataBase Reference: N-(2-Nitrophenyl)phosphoric TriaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-Nitrophenyl)phosphoric TriaMide(874819-71-3)
• EPA Substance Registry System: N-(2-Nitrophenyl)phosphoric TriaMide(874819-71-3)

Safety Data

• Hazardous Substances Data: 874819-71-3(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

(2-Nitrophenyl)phosphoric triamide is used in the preparation of N-phenylphosphoric acid triamides derivatives as agents for regulating or inhibiting enzymatic urea hydrolysis.

Flammability and Explosibility

Nonflammable

Upstream product

• 100868-50-6 (2-Nitro-anilino)-phosphorsaeure-dichlorid 

Relevant articles and documents

Design, synthesis, and biological evaluation of phosphoramide derivatives as urease inhibitors

The design, synthesis, and biological evaluation of phosphoramide derivatives as urease inhibitors to reduce the loss of ammonia has been carried out. Forty phosphorus derivatives were synthesized and their inhibitory activities evaluated against that of jack bean urease. In addition, in vivo assays have been carried out. All of the compounds were characterized by IR, 1H NMR, MS, and elemental microanalysis. In some cases, detailed molecular modeling studies were carried out, and these highlighted the interaction between the enzyme active center and the compounds and also the characteristics related to their activity as urease inhibitors. According to the IC50 values for in vitro inhibitory activity, 12 compounds showed values below 1 μM and 8 of them represent improvements of activity in comparison to the commercial urease inhibitor N-n-butylthiophosphorictriamide (NBPT) (100 nM) (AGROTAIN). On the basis of the activity results and the conclusions of the molecular modeling study, a structural model for new potential inhibitors has been defined.