875433-22-0Relevant articles and documents
Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted γ-keto carboxylic acids
Ma, Dawei,Jiang, Yongwen,Chen, Fangping,Gong, Li-Kun,Ding, Ke,Xu, Yong,Wang, Renxiao,Ge, Aihua,Ren, Jin,Li, Jingya,Li, Jia,Ye, Qizhuang
, p. 456 - 458 (2007/10/03)
The synthesis and matrix metalloproteinase (MMP) inhibitory activity of a series of γ-keto carboxylic acids are described. Among nine MMP isozymes tested, compound 1j displays selective inhibition of MMP-2, -9, and -12 with IC50 values between