87720-55-6

Basic information

• Product Name: Fmoc-4,5-dehydro-L-leucine
• Synonyms: FMOC-ALPHA,BETA-DEHYDRO-LEUCINE;FMOC-4,5-DEHYDRO-LEUCINE;FMOC-4,5-DEHYDRO-LEU-OH;FMOC-4,5-DEHYDRO-L-LEUCINE;FMOC-4,5-DEHYRO-LEU-OH;FMOC-2,3-DEHYDROLEU-OH;FMOC-DELTA-LEU-OH;FMOC-DLE(4,5)-OH
• CAS NO: 87720-55-6
• Molecular Formula: C₂₁H₂₁NO₄
• Molecular Weight: 351.4
• Mol File: 87720-55-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 569.8±45.0 °C(Predicted)
• Appearance: /
• Density: 1.223±0.06 g/cm3(Predicted)
• Storage Temp.: -15°C
• PKA: 3.74±0.10(Predicted)
• CAS DataBase Reference: Fmoc-4,5-dehydro-L-leucine(CAS DataBase Reference)
• NIST Chemistry Reference: Fmoc-4,5-dehydro-L-leucine(87720-55-6)
• EPA Substance Registry System: Fmoc-4,5-dehydro-L-leucine(87720-55-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 87720-55-6(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Uses

Fmoc-4,5-dehydro-L-leucine is a reagent in the solid-phase preparation of ε-lysylcarbonylphenoxyacetic acids to study the selective inhibition of human aldose reductase over aldehyde reductase.

Upstream product

• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 87392-13-0 (2S)-2-amino-4-methylpent-4-enoic acid 
• 87325-65-3 (R,S)-2-acetamido-4-methyl-4-pentenoic acid 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 

Relevant articles and documents

Direct incorporation of unprotected ketone groups into peptides during solid-phase synthesis: Application to the one-step modification of peptides with two different biophysical probes for FRET

An amino acid bearing an unprotected ketone group, (2S)-aminolevulinic acid, was incorporated into a synthetic peptide using standard Fmoc-based solid-phase methods. The ketone group remained unharmed during the synthesis and provided a uniquely reactive functional group for covalent modification of the peptide. The ketone and the sulfhydryl group of a cysteine residue elsewhere in the peptide were reacted simultaneously with two different biophysical probes, enabling the site-specific installation of a donor and acceptor pair for FRET in one step without the need for differential side chain protection.

Synthesis of 2>- and 6>-Locust Adipokinetic Hormone

The syntheses of 2>- and 6>-locust adipokinetic hormone (LAKH) by the coupling of N-terminal hexapeptides prepared by the solid-phase method with a common C-terminal tetrapeptide synthesised in solution