877264-44-3

Basic information

• Product Name: 5-FLUORO-2-IODOBENZALDEHYDE
• Synonyms: 5-Fluoro-2-iodobenzaldehyde97%;5-Fluoro-2-iodobenzaldehyde 97%
• CAS NO: 877264-44-3
• Molecular Formula: C₇H₄FIO
• Molecular Weight: 250.01
• Mol File: 877264-44-3.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 256.6 °C at 760 mmHg
• Flash Point: 109 °C
• Appearance: /
• Density: 1.962 g/cm³
• Vapor Pressure: 0.0153mmHg at 25°C
• Refractive Index: 1.64
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 5-FLUORO-2-IODOBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-FLUORO-2-IODOBENZALDEHYDE(877264-44-3)
• EPA Substance Registry System: 5-FLUORO-2-IODOBENZALDEHYDE(877264-44-3)

Safety Data

• Hazardous Substances Data: 877264-44-3(Hazardous Substances Data)

Usage

General Description

5-FLUORO-2-IODOBENZALDEHYDE is a chemical compound with the molecular formula C7H4FIO. It is an aldehyde derivative of benzaldehyde with a fluorine and iodine substituent. 5-FLUORO-2-IODOBENZALDEHYDE is used in organic synthesis as a building block for the production of various pharmaceuticals and agrochemicals. It can also be used as a reagent for the synthesis of heterocyclic compounds and as a precursor for the preparation of fluorescent dyes and materials. Additionally, 5-FLUORO-2-IODOBENZALDEHYDE has been studied for its potential antifungal and antibacterial properties. Overall, this chemical plays a significant role in various research and industrial applications.

InChI:InChI=1/C7H4FIO/c8-6-1-2-7(9)5(3-6)4-10/h1-4H

Upstream product

• 877264-43-2 (5-fluoro-2-iodophenyl)methanol 
• 52548-63-7 5-fluoro-2-iodobenzoic acid 
• 446-08-2 2-amino-5-fluorobenzoic acid 
• 1202897-48-0 methyl 3-fluoro-6-iodobenzoate 
• 319-24-4 2-amino-5-fluoro-benzoic acid methyl ester 

Downstream Products

• 877264-45-4 5-fluoro-2-iodo-N-methylbenzylamine 
• 1370697-32-7 1-(5-fluoro-2-((4-methoxyphenyl)ethynyl)phenyl)-3-phenylprop-2-yn-1-ol 
• 1042369-35-6 5-fluoro-2-((4-methoxyphenyl)ethynyl)benzaldehyde 
• 1382240-39-2 N-allyl-N-(3-(4-fluoro-2-(hydroxy(phenyl)methyl)phenyl)prop-2-yn-1-yl)-4-methylbenzenesulfonamide 
• 1421615-47-5 (S)-tert-butyl [2,2,2-trifluoro-1-(5-fluoro-2-iodophenyl)ethyl]carbamate 
• 1421615-66-8 (S)-tert-butyl 2,2,2-trifluoro-1-(5-fluoro-2-(phenylethynyl)phenyl)ethylcarbamate 
• 1421615-90-8 (S,Z)-tert-butyl 1-benzylidene-5-fluoro-3-(trifluoromethyl)isoindoline-2-carboxylate 
• 1421616-06-9 (S)-tert-butyl 7-fluoro-3-phenyl-1-(trifluoromethyl)isoquinoline-2(1H)-carboxylate 
• 1421615-38-4 (R)-2-methyl-N-[(S)-2,2,2-trifluoro-1-(5-fluoro-2-iodophenyl)ethyl]propane-2-sulfinamide 
• 1213055-28-7 (S)-2,2,2-trifluoro-1-(5-fluoro-2-iodophenyl)ethanamine 

Relevant articles and documents

Rapid Access to Azabicyclo[3.3.1]nonanes by a Tandem Diverted Tsuji–Trost Process

A three-step synthesis of the 2-azabicyclo[3.3.1]nonane ring system from simple pyrroles, employing a combined photochemical/palladium-catalysed approach is reported. Substrate scope is broad, allowing the incorporation of a wide range of functionality relevant to medicinal chemistry. Mechanistic studies demonstrate that the process occurs by acid-assisted C?N bond cleavage followed by β-hydride elimination to form a reactive diene, demonstrating that efficient control of what might be considered off-cycle reactions can result in productive tandem catalytic processes. This represents a short and versatile route to the biologically important morphan scaffold.

Palladium-Catalyzed, Norbornene-Mediated, ortho-Amination ipso-Amidation: Sequential C-N Bond Formation

A palladium-catalyzed, norbornene-mediated ortho- and ipso-C-N bond-forming Catellani reaction is reported. This reaction proceeds through a sequential intermolecular amination followed by intramolecular cyclization of a tethered amide. The products, ortho-aminated dihydroquinolinones, were generated in moderate to good yields and are present in bioactive molecules. This work highlights the challenge of competing intra- vs intermolecular palladium-catalyzed processes.

Intramolecular Pd-Catalyzed Arylation of 1-Amidosugars: A New Route to N-Glycosyl Quinolin-2-ones

The synthesis of N-glycosylated quinolin-2-ones via an intramolecular N-arylation of glycosylamides is reported. The coupling involves the use of only Pd(OAc)2 as the catalyst and nBu4NOAc as the base in 1,4-dioxane. This versatile approach allows the synthesis of various N-glycosylated quinolin-2-ones with exclusive α or β selectivity.