87814-02-6

Basic information

• Product Name: 2(1H)-Pyrimidinone, 5-hydroxy-4,6-dimethyl- (9CI)
• Synonyms: 2(1H)-Pyrimidinone, 5-hydroxy-4,6-dimethyl- (9CI);5-hydroxy-4,6-dimethyl-1H-pyrimidin-2-one
• CAS NO: 87814-02-6
• Molecular Formula: C₆H₈N₂O₂
• Molecular Weight: 140.13992
• Product Categories: PYRIMIDINE
• Mol File: 87814-02-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2(1H)-Pyrimidinone, 5-hydroxy-4,6-dimethyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Pyrimidinone, 5-hydroxy-4,6-dimethyl- (9CI)(87814-02-6)
• EPA Substance Registry System: 2(1H)-Pyrimidinone, 5-hydroxy-4,6-dimethyl- (9CI)(87814-02-6)

Safety Data

• Hazardous Substances Data: 87814-02-6(Hazardous Substances Data)

Usage

Class

Pyrimidines

Derivative

2(1H)-pyrimidinone

Biological activity

Inhibitor of dihydroorotate dehydrogenase enzyme

Involvement in

Pyrimidine biosynthesis

Potential use

Treatment of cancer and autoimmune diseases

Investigation as

Lead compound for new drug development

Area of research

Medicinal chemistry

Upstream product

• 34289-60-6 4,6-dimethyl-2-hydroxy-pyrimidine hydrochloride 
• 108-79-2 4,6-dimethylpirimidin-2-one 
• 4214-57-7 2-amino-5-bromo-4,6-dimethylpyrimidine 
• 767-15-7 2-Amino-4,6-dimethylpyrimidine 
• 87814-14-0 sulfuric acid mono-(4,6-dimethyl-2-oxo-1,2-dihydro-pyrimidin-5-yl ester) 
• 685897-68-1 2-amino-4,6-dimethyl-5-pyrimidinol 

Relevant articles and documents

Application of the Elbs Persulfate Oxidation to the Preparation of 5-Hydroxypyrimidines

The use of potassium persulfate in cold sodium hydroxide solution has been shown to give the pyrimidin-5-yl hydrogen sulfates in cases where the pyrimidine has at least two electron-releasing groups in the 2, 4 or 6 positions.However, the reaction has been unsuccessful in a number of cases.The pyrimidin-5-yl hydrogen sulfates are hydrolysed to the corresponding 5-hydroxypyrimidines by hydrochloric acid.