87987-99-3Relevant articles and documents
Addressing PXR liabilities of phthalazine-based hedgehog/smoothened antagonists using novel pyridopyridazines
Kaizerman, Jacob A.,Aaron, Wade,An, Songzhu,Austin, Richard,Brown, Matt,Chong, Angela,Huang, Tom,Hungate, Randall,Jiang, Ben,Johnson, Michael G.,Lee, Gary,Lucas, Brian S.,Orf, Jessica,Rong, Minqing,Toteva, Maria M.,Wickramasinghe, Dineli,Xu, Guifen,Ye, Qiuping,Zhong, Wendy,McMinn, Dustin L.
scheme or table, p. 4607 - 4610 (2010/10/02)
Pyridopyridazine antagonists of the hedgehog signaling pathway are described. Designed to optimize our previously described phthalazine smoothened antagonists, a representative compound eliminates a PXR liability while retaining potency and in vitro metab
Synthesis of isomeric pyridooxazinones, pyridopyridazines and triazolopyridopyridazines from o-aroylpyridinecarboxylic acids
Youssef, Mohamed Salah K.,Fahmy, Amin F.,Abdel Halim, Mohamed S.,Hassan, Mamdouh A.,Sauer, Juergen
, p. 247 - 256 (2007/10/03)
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