880-93-3 Usage
Description
1-METHYL-4-NITRONAPHTHALENE is an organic compound with the chemical formula C11H9NO2. It is a yellow crystalline solid that is soluble in organic solvents and has a molecular weight of 189.19 g/mol. 1-METHYL-4-NITRONAPHTHALENE is characterized by the presence of a methyl group attached to the first carbon atom and a nitro group attached to the fourth carbon atom of the naphthalene ring. Due to its unique chemical structure, 1-METHYL-4-NITRONAPHTHALENE has potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
1-METHYL-4-NITRONAPHTHALENE is used as a key intermediate in the synthesis of S-triazolyl α-mercaptoacetanilides, which are inhibitors of HIV reverse transcriptase. These compounds play a crucial role in the development of antiretroviral drugs, as they help in the treatment and management of HIV/AIDS by inhibiting the replication of the virus.
In the preparation of S-triazolyl α-mercaptoacetanilides, 1-METHYL-4-NITRONAPHTHALENE serves as a starting material, which undergoes a series of chemical reactions to form the desired active pharmaceutical ingredients. The synthesis process typically involves the formation of a triazole ring, followed by the introduction of a mercaptoacetanilide moiety. The resulting compounds exhibit potent inhibitory activity against HIV reverse transcriptase, making them valuable candidates for further research and development in the field of antiretroviral therapy.
Check Digit Verification of cas no
The CAS Registry Mumber 880-93-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 8,8 and 0 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 880-93:
(5*8)+(4*8)+(3*0)+(2*9)+(1*3)=93
93 % 10 = 3
So 880-93-3 is a valid CAS Registry Number.
InChI:InChI=1/C11H9NO2/c1-8-6-7-11(12(13)14)10-5-3-2-4-9(8)10/h2-7H,1H3
880-93-3Relevant articles and documents
1,4-SUBSTITUTED ISOQUINOLINE INHIBITORS OF KEAP1/NRF2 PROTEIN-PROTEIN INTERACTION
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Paragraph 00101, (2019/10/29)
Disclosed herein are compounds that can act as inhibitors of the Kelch-like ECH- associated protein 1/nuclear factor (erythroid-derived 2)-like 2 ("KEAP1/NRF2") protein- protein interaction, and methods of using the compounds to treat and prevent diseases and disorders, such as COPD, multiple sclerosis, and diabetes, and in the promotion of wound healing. The compounds described herein can include compounds of Formula (I) and pharmaceutically acceptable salts thereof: formula (I), wherein the substituents are as described.
Green and controllable metal-free nitrification and nitration of arylboronic acids
Wang, Shuai,Shu, Chun Chun,Wang, Tao,Yu, Jian,Yan, Guo Bing
scheme or table, p. 643 - 646 (2012/08/07)
A novel and green nitrating reagent has been developed for the nitrification and nitration of arylboronic acids, which can be controlled by the reaction conditions. The process provides an attractive alternative to the traditional nitration protocols.
Aromatic nitration in liquid Ag0.51K0.42Na 0.07NO3
Mascal, Mark,Yin, Lunxiang,Edwards, Ross,Jarosh, Michael
, p. 6148 - 6151 (2008/12/22)
(Figure Presented) Aromatic molecules have a strong affinity for silver(I) and dissolve to a limited extent in Ag0.51K0.42Na 0.07NO3, a low-melting eutectic mixture of silver, potassium, and sodium nitrates. Aromatic nitration in this inorganic ionic liquid leads to products which arise from nonelectrophilic substitution pathways.