88043-21-4Relevant articles and documents
Selective CDK6 degradation mediated by cereblon, VHL, and novel IAP-recruiting PROTACs
Ahmed, Adil,Anderson, Niall A.,Benowitz, Andrew B.,Cryan, Jenni,Dai, Han,McGonagle, Grant A.,Rozier, Christine
, (2020)
Inhibitors of CDK4 and CDK6 have emerged as important FDA-approved treatment options for breast cancer patients. The properties and pharmacology of CDK4/6 inhibitor medicines have been extensively profiled, and investigations into the degradation of these
CELL-PENETRATING GLYCOSAMINOGLYCAN MIMETICS
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Page/Page column 19, (2019/02/02)
This invention relates to a glycosaminoglycan mimetic molecule comprising a polyproline backbone, an anionic pendant group and a fluorophore. The invention also relates to the use of the glycosaminoglycan mimetic molecule for internalizing a target molecule into a cell, a method for internalizing a target molecule into the cell, and a method for synthesizing a glycosaminoglycan mimetic molecule. [No suitable figure]
Preparation method of antihypertensive medicine key intermediate of trans-4-cyclohexyl-L-proline
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Paragraph 0032-0034, (2018/11/22)
The invention discloses a preparation method of trans-4-cyclohexyl-L-proline. The method comprises the following steps of (1) under the effect of an acid-binding agent, 4S-hydroxy-N-Boc-L-proline ester 6 and sulfonyl chloride are subjected to condensation to generate sulphonate 5, wherein R is C1-4 alkyl; (2) under the effects of a copper catalyst, lithium salt and organic alkali, the sulphonate 5and cyclohexylmagnesium bromide take nucleophilic substitution to generate a compound 4; (3) the compound 4 is hydrolyzed by lithium hydroxide to obtain (4S)-N-Boc-4-cyclohexyl-L-proline (a compound3); (4) the compound 3 is subjected to Boc removal under the condition of hydrochloric acid or trifluoroacetic acid/methylene dichloride; a target product 2 is prepared. The preparation method has thebeneficial effects that the target product structure and chirality are introduced through sulphonate and Grignard reagent nucleophilic substitution; the defects of the existing noble metal reductionmethod are overcome; the operation of the method is simple; the conditions are mild; the yield is good; the chemical purity and the optical purity are very high; the preparation method is suitable forindustrial production.