881-89-0

Basic information

• Product Name: phenyl 2-thiophenecarboxylate
• Synonyms: phenyl 2-thiophenecarboxylate
• CAS NO: 881-89-0
• Molecular Formula: C₁₁H₈O₂S
• Molecular Weight: 204.24502
• Mol File: 881-89-0.mol
• Article Data: 30

Chemical Properties

• Appearance: /
• CAS DataBase Reference: phenyl 2-thiophenecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: phenyl 2-thiophenecarboxylate(881-89-0)
• EPA Substance Registry System: phenyl 2-thiophenecarboxylate(881-89-0)

Safety Data

• Hazardous Substances Data: 881-89-0(Hazardous Substances Data)

Upstream product

• 5271-67-0 2-Thiophenecarbonyl chloride 
• 108-95-2 phenol 
• 30930-49-5 bis(2-thiophenecarbonyl) peroxide 
• 71-43-2 benzene 
• 527-72-0 2-thiophenylcarboxylic acid 
• 201230-82-2 carbon monoxide 
• 91228-44-3 2-thienylphenyliodonium tosylate 
• 591-50-4 iodobenzene 
• 108-86-1 bromobenzene 
• 108-90-7 chlorobenzene 
• 96-43-5 2-thienyl chloride 
• 98-03-3 thiophene-2-carbaldehyde 
• 98-80-6 phenylboronic acid 
• 2751-90-8 tetraphenylphosphonium bromide 

Downstream Products

• 20409-64-7 (2-hydroxyphenyl)(thiophen-2-yl)methanone 
• 97034-91-8 2-thienyl 2'-hydroxyphenyl ketone oxime 
• 97035-10-4 C₁₃H₁₁NO₃S 
• 833-50-1 2-phenylbenzo[d]oxazole 
• 10354-43-5 thiophene-2-carboxylic acid benzylamide 
• 56966-27-9 diphenyl(thiophen-2-yl)phosphine oxide 
• 58042-63-0 2-(p-tolylsulfanyl)thiophene 
• 89942-95-0 4-methyl-2-(2-thienyl)-thiazole 
• 96461-08-4 5-phenyl-2-(thiophen-2-yl)thiazole 
• 42140-95-4 2-(thiophen-2-yl)thiazole 
• 6846-13-5 N-phenyl-2-thiophenecarboxamide 

Relevant articles and documents

Transition-Metal-Free DMAP-Mediated Aromatic Esterification of Amides with Organoboronic Acids

A new, transition-metal-free, effective method for aromatic esterification of amides with organoboronic acids has been developed. A wide range of benzoate derivatives were obtained with yields ranging from moderate to good. The catalytic reaction shows a broad substrate scope and excellent functional group tolerance. Conceptually, DMAP mediates the reaction and is crucial for this transformation.

Hydrogen-bond-assisted transition-metal-free catalytic transformation of amides to esters

The amide C-N cleavage has drawn a broad interest in synthetic chemistry, biological process and pharmaceutical industry. Transition-metal, luxury ligand or excess base were always vital to the transformation. Here, we developed a transition-metal-free hydrogen-bond-assisted esterification of amides with only catalytic amount of base. The proposed crucial role of hydrogen bonding for assisting esterification was supported by control experiments, density functional theory (DFT) calculations and kinetic studies. Besides broad substrate scopes and excellent functional groups tolerance, this base-catalyzed protocol complements the conventional transition-metal-catalyzed esterification of amides and provides a new pathway to catalytic cleavage of amide C-N bonds for organic synthesis and pharmaceutical industry. [Figure not available: see fulltext.]

Palladium-Catalyzed Aerobic Oxidative Coupling of Amides with Arylboronic Acids by Cooperative Catalysis

The first fluoride and palladium co-catalyzed conversion of amide to ester through an aerobic oxidative coupling pathway is reported. This new approach presents a practical process that employs easily available oxygen and commercially available arylboronic acids as coupling partners, uses a wide range of N- tosylamides, and proceeds under mild reaction conditions. This protocol demonstrates broad functional group tolerance, and provides an alternative option to synthesize esters from N-tosylamides which obtained by simply N-functionalization of secondary amides.