88150-62-3

Basic information

• Product Name: Phthaloyl amlodipine
• Synonyms: 3-Ethyl-5-methyl-4-(2-chlorophenyl)-2-(2-phthalimidoethoxyl)methyl-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate;4-(2-Chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-2-(phthalimidoethoxy)methyl-1,4-dihydropyridine;Phthalimidoamlodipine;3-ethyl 5-methyl 4-(2-chlorophenyl)-1,4-dihydro-2-[2-(1,3-dihydro-1,3-dioxo-(2H)isoindol-2-yl)-ethoxymethyl]-6-methyl-3,5-pyridinedicarboxylate;1-Amino-6-fluoro-1,4-dihydro-7-(4-((5-methyl-2-oxo-1,3-dioxol-4-yl)methyl)piperazin-1-yl)-4-oxo-[1,3]thiazeto[3,2-A]quinoline-3-carboxylic acid;3,5-Pyridinedicarboxylicacid,4-(2-chlorophenyl)-2-[[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]Methyl]-1,4-dihydro-6-Methyl-,3-ethyl 5-Methyl ester;4-(2-Chlorophenyl)-3-Ethoxy carbonyl-5-Methoxy carbonil-6-Methyl-2-(phthaliMidoethoxy)Methyl-1,4-dihydropyridine;4-(2-Chlorophenyl)-2-[[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]Methyl]-1,4-dihydro-6-Methyl-3,5-pyridinedicarboxylic Acid 3-Ethyl 5-Methyl Ester
• CAS NO: 88150-62-3
• Molecular Formula: C₂₈H₂₇ClN₂O₇
• Molecular Weight: 538.98
• EINECS: 413-410-3
• Product Categories: API intermediates;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 88150-62-3.mol
• Article Data: 16

Chemical Properties

• Melting Point: 140-145°C
• Boiling Point: 654.061 °C at 760 mmHg
• Flash Point: 349.364 °C
• Appearance: /
• Density: 1.321 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.589
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly, Heated and Sonicated)
• PKA: 2.06±0.70(Predicted)
• CAS DataBase Reference: Phthaloyl amlodipine(CAS DataBase Reference)
• NIST Chemistry Reference: Phthaloyl amlodipine(88150-62-3)
• EPA Substance Registry System: Phthaloyl amlodipine(88150-62-3)

Safety Data

• Statements: 53
• Safety Statements: 61
• Hazardous Substances Data: 88150-62-3(Hazardous Substances Data)

Usage

Description

Phthaloyl amlodipine is an intermediate compound derived from the synthesis of amlodipine, a widely used calcium channel blocker for the treatment of hypertension, angina, and certain heart conditions. It plays a crucial role in the production process of amlodipine, ensuring the quality and efficacy of the final drug product.

Uses

Used in Pharmaceutical Industry:
Phthaloyl amlodipine is used as an intermediate in the synthesis of amlodipine for the treatment of hypertension, angina, and certain heart conditions. It contributes to the development of amlodipine-related compounds, such as Amlodipine Related Compound A, which may have potential therapeutic applications.
Used in Chemical Synthesis:
Phthaloyl amlodipine is used as a key intermediate in the chemical synthesis of amlodipine, ensuring the production of a high-quality and effective medication for cardiovascular diseases. Its role in the synthesis process is essential for the development of innovative and improved pharmaceutical formulations.

InChI:InChI=1/C28H27ClN2O7/c1-4-38-28(35)24-21(15-37-14-13-31-25(32)17-9-5-6-10-18(17)26(31)33)30-16(2)22(27(34)36-3)23(24)19-11-7-8-12-20(19)29/h5-12,23,30H,4,13-15H2,1-3H3

Upstream product

• 89-98-5 2-chloro-benzaldehyde 
• 14205-39-1 methyl (E)-3-aminocrotonate 
• 88150-75-8 ethyl 4-[2-(phthalimido)ethoxy]acetoacetate 
• 14205-39-1 methyl 3-aminocrotonate 
• 3891-07-4 N-(2-Hydroxyethyl)phthalimide 
• 638-07-3 ethyl (2-chloroaceto)acetate 
• 21731-17-9 methyl 3-aminocrotonate 
• 67593-46-8 methyl (Z)-2-acetyl-3-(2-chlorophenyl)acrylate 
• 265136-65-0 ethyl (E)-3-amino-4-[2-(phthalimido)ethoxy]crotonate 
• 85-44-9 phthalic anhydride 
• 400024-08-0 ethyl 2-(2-chlorobenzylidene)-4-[(2-phthalimido)ethoxy]acetoacetate 
• 1074-82-4 potassium phtalimide 
• 13176-46-0 4-bromoethyl acetoacetate 

Downstream Products

• 88150-42-9 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine 
• 113994-41-5 2-(2-Amino-ethoxymethyl)-4-(2-chloro-phenyl)-6-methyl-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester 
• 93849-02-6 2-({2-[(morpholinosulfonyl)amino]ethoxy}methyl)-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine 
• 721958-72-1 3-ethyl-5-methyl-(4-RS)-4-(2-chlorophenyl)-6-[[2-((2-methylcarbamoyl)benzoyl)aminoethoxy]methyl]-1,4-dihydropyridine-3,5-dicarboxylate 
• 88150-47-4 (RS)-amlodipine maleate 
• 1064653-84-4 acetone solvate of 3-ethyl, 5-methyl 4-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-[(2-phthalimidoethoxy)methyl]-3,5-pyridinedicarboxylate 
• 111470-99-6 amlodipine besylate 

Relevant articles and documents

Method for preparing amlodipine besylate intermediate by using micro-reaction device

The invention provides a method for producing an amlodipine besylate intermediate by using a micro-reaction device. According to the method, o-chlorobenzaldehyde is used as a raw material, the amlodipine besylate intermediate is rapidly and safely prepared by using the micro-reaction device, and the method has the advantages of high reaction conversion rate, simple post-treatment, small reaction volume, short reaction time, low energy consumption and the like, and has relatively high commercial value.

Synthesis technology of amlodipine maleate

The invention discloses a synthesis technology of amlodipine maleate and relates to the technical field of medicine synthesis, aiming at solving the problem in an existing synthesis technology that more byproducts and impurities exist in industrial production. By controlling parameters of the synthesis technology and reducing the content of the impurities, the purity of the prepared amlodipine maleate reaches 99.5 percent; the self-made amlodipine maleate is used as a raw material for further preparing the amlodipine maleate, so that the cost of a product is reduced and the quality controllability of the product is strong.

Using the new crystal form [...] and production of high-purity [...]

PROBLEM TO BE SOLVED: To provide a process for producing high-purity phthaloyl amlodipine for synthesis of an amlodipine besilate having excellent purity as a medicine.SOLUTION: Provided are TW-A type and TW-B type crystal forms of highly pure phthaloyl amlodipine. In powder X-ray diffraction, the TW-A type phthaloyl amlodipine has diffraction peaks at 2θ(°)=8.7±0.2, 11.0±0.2, 13.4±0.2, 15.7±0.2, and 24.6±0.2. In powder X-ray diffraction, the TW-B type phthaloyl amlodipine has diffraction peaks at 2θ(°)=6.6±0.2, 9.9±0.2, 11.1±0.2, 17.3±0.2, and 24.4±0.2.