88214-48-6

Basic information

• Product Name: 3-(2-hydroxyethyl)-3-methyloxetane
• Synonyms: 3-(2-hydroxyethyl)-3-methyloxetane;2-(3-Methyloxetan-3-yl)ethanol;3-Methyl-3-oxetaneethanol
• CAS NO: 88214-48-6
• Molecular Formula: C₆H₁₂O₂
• Molecular Weight: 116
• Mol File: 88214-48-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 196℃
• Flash Point: 81℃
• Appearance: /
• Density: 1.005
• PKA: 14.95±0.10(Predicted)
• CAS DataBase Reference: 3-(2-hydroxyethyl)-3-methyloxetane(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-hydroxyethyl)-3-methyloxetane(88214-48-6)
• EPA Substance Registry System: 3-(2-hydroxyethyl)-3-methyloxetane(88214-48-6)

Safety Data

• Hazardous Substances Data: 88214-48-6(Hazardous Substances Data)

Usage

General Description

3-(2-hydroxyethyl)-3-methyloxetane, also known as MTHF (methyltetrahydrofuran), is a unique chemical compound that is used in a variety of applications. It is a clear, colorless liquid with a mildly sweet odor. MTHF is commonly used as a solvent and as a replacement for toxic solvents in various chemical processes. It is also used as a solvent in the production of pharmaceuticals, agrochemicals, and other specialty chemicals. MTHF is known for its high boiling point, low viscosity, and low toxicity, making it a versatile and environmentally friendly alternative to traditional solvents. Additionally, due to its unique chemical structure, MTHF is also being studied for its potential use in energy storage and transportation applications.

Upstream product

• 88214-46-4 3-(2-(benzyloxy)ethyl)-3-methyloxetane 
• 88214-45-3 2-(2-(benzyloxy)ethyl)-2-methylpropane-1,3-diol 
• 88214-44-2 ethyl 4-benzyloxy-2-methoxycarbonyl-2-methylbutanoate 
• 88214-47-5 C₁₉H₃₇N₃O₃P⁽¹⁺⁾*Cl^(1-) 
• 1453272-38-2 ethyl 2-(3-methyloxetan-3-yl)acetate 
• 922500-91-2 ethyl 2-(oxetan-3-ylidene)acetate 

Downstream Products

• 1123786-92-4 (S)-(3-methyltetrahydrofuran-3-yl)methanol 

Relevant articles and documents

Asymmetric Desymmetrization of Oxetanes for the Synthesis of Chiral Tetrahydrothiophenes and Tetrahydroselenophenes

Chiral tetrahydrothiophenes and tetrahydroselenophenes are highly useful structural units. Described here is a new catalytic asymmetric approach for their synthesis. With a suitable chiral Br?nsted acid catalyst, an oxetane desymmetrization by a well-positioned internal sulfur or selenium nucleophile proceeded efficiently to generate all-carbon quaternary stereocenters with excellent enantioselectivities. Taming the sulfur and selenium nucleophile in the form of a thioester and selenoester, respectively, is crucial to the success of this work. This approach also allows the facile synthesis of chiral tetrahydrothiopyrans. Mechanistic studies, including DFT calculations, suggested an intramolecular acyl-transfer pathway. Utilities of the chiral products are also demonstrated.

Sulphone-based Elimination Reactions in Synthesis. Part 2. Diumycinol

Diumycinol , a hydrolytic product of the antibiotic diumycin, was assembled from three fragments: 1-(2-phenylsulphonylethyl)-2-methylene-6,6-dimethylcyc