882176-52-5Relevant articles and documents
Asymmetric catalytic synthesis of P-stereogenic phosphines via a nucleophilic ruthenium phosphide complex
Chan, Vincent S.,Stewart, Ian C.,Bergman, Robert G.,Dean Toste
, p. 2786 - 2787 (2006)
Ruthenium phosphido complexes have been shown to be excellent nucleophiles, reacting via two-electron processes with a variety of electrophiles. A catalytic alkylation reaction was developed using an achiral ruthenium complex, which was then elaborated into a catalytic enantioselective synthesis of P-stereogenic phosphines. These useful and synthetically challenging phosphines can now be accessed in a single step from simple secondary phosphines and alkyl halides. Optimization and scope of the enantioselective alkylation are discussed. Copyright
