882182-35-6Relevant articles and documents
Stereoselective synthesis of 2,4-methanoproline homologues
Grygorenko, Oleksandr O.,Artamonov, Oleksiy S.,Palamarchuk, Gennady V.,Zubatyuk, Roman I.,Shishkin, Oleg V.,Komarov, Igor V.
, p. 252 - 258 (2006)
The stereoselective synthesis of 2-azabicyclo[2.2.1]heptane-1-carboxylic acid and 6-azabicyclo[3.2.1]octane-5-carboxylic acid, novel rigid bicyclic proline analogues, is reported. The synthesis was performed in five steps from the corresponding 2-cycloalk
NOVEL INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP)
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Page/Page column 46-47, (2009/04/24)
A compound having the structure set forth in Formula (I): wherein the variables Y, R1, R2, R3, R4 and R5 are as defined herein. Compounds described herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of such compounds and pharmaceutical compositions to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity