882670-92-0

Basic information

• Product Name: 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinazolin-2-amine
• Synonyms: 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinazolin-2-amine;2-Aminoquinazoline-6-boronic acid pinacol ester;6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-quinazolinamine;(2-AMINOQUINAZOLIN-6-YL)BORONIC ACID PINACOL ESTER
• CAS NO: 882670-92-0
• Molecular Formula: C₁₄H₁₈BN₃O₂
• Molecular Weight: 271.12262
• Mol File: 882670-92-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 473.5±37.0 °C(Predicted)
• Appearance: /
• Density: 1.19
• Storage Temp.: 2-8°C(protect from light)
• PKA: 4.97±0.26(Predicted)
• CAS DataBase Reference: 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinazolin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinazolin-2-amine(882670-92-0)
• EPA Substance Registry System: 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinazolin-2-amine(882670-92-0)

Safety Data

• Hazardous Substances Data: 882670-92-0(Hazardous Substances Data)

Usage

General Description

6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinazolin-2-amine is a chemical compound with potential applications in pharmaceutical research and drug development. It is a quinazoline derivative containing a boron-containing heterocycle, which may contribute to its unique properties and potential pharmacological activities. The compound's specific chemical structure may make it suitable for various medicinal chemistry applications, including the development of new drugs targeting specific biological pathways or disease mechanisms. Its potential use in medicinal chemistry and pharmaceutical research makes it a subject of interest for further investigation and development.

Upstream product

• 190273-89-3 6-bromoquinazolin-2-ylamine 
• 73183-34-3 bis(pinacol)diborane 
• 93777-26-5 5-bromo-2-fluorobenzaldehyde 

Downstream Products

• 882670-96-4 3-(2-amino-6-quinazolinyl)-4-methylbenzoic acid 
• 1003312-16-0 6-(2-(4-methoxybenzyloxy)-4-methylpyridin-3-yl)quinazolin-2-amine 

Relevant articles and documents

INHIBITOR OF BRUTON'S TYROSINE KINASE

Disclosed herein is a compound of Formula (I) with a Btk inhibitory activity, wherein all the variables are as defined herein. The compound can be used for the treatment of diseases such as autoimmune diseases, xenogeneic immune diseases, cancers or thromboembolic diseases. Also disclosed is a pharmaceutical composition comprising a compound of Formula (I). Futher provided is a compound capable of inhibiting the activity of Bruton's tyrosine kinase by covalent binding.

PYRIDOPYRIMIDINE COMPOUNDS ACTING AS MTORC 1/2 DOUBLE-KINASE INHIBITORS

Disclosed are a series of pyridopyrimidine compounds and a use of same in the preparation of drugs associated with mTORC 1/2 dual complex inhibitors, and specifically disclosed is a use of the compounds as shown in formula (IV), tautomers thereof or pharmaceutically acceptable salts thereof in the preparation of drugs associated with mTORC 1/2 dual complex inhibitors.

Discovery of aryl aminoquinazoline pyridones as potent, selective, and orally efficacious inhibitors of receptor tyrosine kinase c-Kit

Inhibition of c-Kit has the potential to treat mast cell associated fibrotic diseases. We report the discovery of several aminoquinazoline pyridones that are potent inhibitors of c-Kit with greater than 200-fold selectivity against KDR, p38, Lck, and Src.