882772-93-2Relevant articles and documents
Synthesis and antimicrobial activity of azepine and thiepine derivatives
Boinovi, Nina,Novakovi, Irena,Rajai, Sladana Kosti,Opsenica, Igor M.,olaja, Bogdan A.
, p. 839 - 852 (2015/08/24)
A series of new pyridobenzazepine and pyridobenzothiepine derivatives was synthesized by Pd-catalyzed formation of C-N and C-S bonds. All synthesized compounds were tested for their in vitro antimicrobial activity. The pyridobenzazepine derivatives showed better antibacterial and antifungal activity than the corresponding dipyridoazepine analogue. Among the synthesized azepines, derivative 8 displayed potent activity against the tested bacteria (MIC ranged 39-78 μg mL-1), while azepine 12 showed promising antifungal activity (MIC ranged 156-313 μg mL-1). The synthesized thiepine derivatives exhibited weak antibacterial activity, but showed pronounced antifungal activity.