882855-95-0

Basic information

• Product Name: (2-AMINO-5-BROMO-PHENYL)-ACETONITRILE
• Synonyms: (2-AMINO-5-BROMO-PHENYL)-ACETONITRILE
• CAS NO: 882855-95-0
• Molecular Formula: C₈H₇BrN₂
• Molecular Weight: 211.06
• Product Categories: Aromatic Building Blocks
• Mol File: 882855-95-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 345.2±27.0 °C(Predicted)
• Appearance: /
• Density: 1.573±0.06 g/cm3(Predicted)
• PKA: 2.89±0.10(Predicted)
• CAS DataBase Reference: (2-AMINO-5-BROMO-PHENYL)-ACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: (2-AMINO-5-BROMO-PHENYL)-ACETONITRILE(882855-95-0)
• EPA Substance Registry System: (2-AMINO-5-BROMO-PHENYL)-ACETONITRILE(882855-95-0)

Safety Data

• Hazardous Substances Data: 882855-95-0(Hazardous Substances Data)

Usage

Description

(2-AMINO-5-BROMO-PHENYL)-ACETONITRILE is a chemical compound with the molecular formula C8H6BrN2. It features a five-membered aromatic ring with a bromine atom and an amino group attached, as well as a nitrile group. (2-AMINO-5-BROMO-PHENYL)-ACETONITRILE is recognized for its potential applications in the pharmaceutical and agrochemical industries, where it serves as a building block in the synthesis of various biologically active compounds. The presence of bromo and amino functional groups renders it a valuable intermediate for the preparation of novel heterocyclic compounds and pharmaceuticals. Furthermore, it may also find use as an intermediate in the production of dyes and other organic compounds.

Uses

Used in Pharmaceutical Industry:
(2-AMINO-5-BROMO-PHENYL)-ACETONITRILE is used as a key intermediate in the synthesis of biologically active compounds, contributing to the development of new pharmaceuticals. Its unique structure allows for the creation of novel heterocyclic compounds with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, (2-AMINO-5-BROMO-PHENYL)-ACETONITRILE is utilized as a building block for the synthesis of various agrochemicals, including pesticides and herbicides. Its functional groups facilitate the development of effective compounds for agricultural use.
Used in Dye Production:
(2-AMINO-5-BROMO-PHENYL)-ACETONITRILE is used as an intermediate in the production of dyes, where its chemical properties enable the creation of a range of colorants for various applications, including textiles and other industries.
Used in Organic Compounds Synthesis:
(2-AMINO-5-BROMO-PHENYL)-ACETONITRILE also serves as an intermediate in the synthesis of other organic compounds, broadening its applications across different chemical domains and contributing to the development of new materials and products.

Upstream product

• 2973-50-4 2-aminophenylacetonitrile 
• 610-66-2 2-nitro-benzeneacetonitrile 
• 125914-22-9 2-(5-bromo-2-nitrophenyl)acetonitrile 
• 586-78-7 para-nitrophenyl bromide 

Downstream Products

• 1378862-87-3 4-amino-3-cyanomethylbenzonitrile 
• 201227-39-6 5-bromo-1H-indazole-3-carbonitrile 
• 1190319-99-3 methyl 3-cyano-1H-indazole-5-carboxylate 
• 83515-06-4 5-bromo-2-phenylindole 
• 76609-17-1 5-bromo-2-(4-fluorophenyl)-1H-indole 
• 881040-30-8 5-bromo-2-(4-chlorophenyl)-1H-indole 
• 851530-48-8 5-bromo-2-(4-methoxyphenyl)-1H-indole 
• 89671-79-4 (5-bromo-1H-indol-2-yl)(4-bromophenyl)methanone 

Relevant articles and documents

Modular Synthesis of Polysubstituted Quinolin-3-amines by Oxidative Cyclization of 2-(2-Isocyanophenyl)acetonitriles with Organoboron Reagents

Polysubstituted quinolin-3-amines are vital structural motifs because of their broad biological activities as well as versatile transformational abilities. However, they are not easily accessible. We disclose a protocol with Mn(III) acetate as a mild one-

Method for synthesizing indole derivative

The invention relates to a method for synthesizing an indole derivative shown in the formula (III) (please see the specification). The method includes the steps that in a solvent and inertia gas atmosphere, when a catalyst, a nitrogen-containing ligand, an acid accelerator and KF exist, a compound in the formula (I) (please see the specification) and a compound in the formula (II) (please see the specification) are reacted, aftertreatment is carried out after the reaction is completed, and therefore the compound in the formula (III) is obtained, wherein R1 is selected from H or halogen, and R2 is selected from H, C1-C6 alkyl, C1-C6 alkoxy or halogen. According to the method, as a proper substrate, the proper catalyst, the proper nitrogen-containing ligand, the proper acid accelerator, the proper KF, the proper solvent and the like are comprehensively selected and cooperated, the range of the substrate is expanded accordingly, the indole derivative can be obtained with the good yield, the method has good application prospects and research value in the field of organic chemistry synthesis, and a brand new method is provided for synthesis of the compound.

N2-PYRAZOLOSPIROKETONE ACETYL-COA CARBOXYLASE INHIBITORS

The invention provides a compound of Formula (I) or a pharmaceutically acceptable salt of said compound, wherein R1, R2, R3 and R4 are as described herein; pharmaceutical compositions thereof; and the use thereof in treating diseases, conditions or disorders modulated by the inhibition of an acetyl- CoA carboxylase enzyme(s) in an animal.