88303-16-6

Basic information

• Product Name: Benzenesulfonamide, N-cyclohexyl-N-fluoro-4-methyl-
• CAS NO: 88303-16-6
• Molecular Formula: C13H18FNO2S
• Molecular Weight: 271.356
• Mol File: 88303-16-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, N-cyclohexyl-N-fluoro-4-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, N-cyclohexyl-N-fluoro-4-methyl-(88303-16-6)
• EPA Substance Registry System: Benzenesulfonamide, N-cyclohexyl-N-fluoro-4-methyl-(88303-16-6)

Safety Data

• Hazardous Substances Data: 88303-16-6(Hazardous Substances Data)

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 108-91-8 cyclohexylamine 
• 80-30-8 N-cyclohexyl-p-toluenesulfonamide 

Relevant articles and documents

Direct Synthesis of α-Amino Nitriles from Sulfonamides via Base-Mediated C-H Cyanation

Herein, we disclose a transition-metal-free reaction system that enables α-cyanation of sulfonamides through C-H bond cleavage for the preparation of α-amino nitriles, including difficult-to-access all-alkyl α-tertiary scaffolds. More than 50 substrate examples prove a wide functional group tolerance. Additionally, its synthetic practicality is highlighted by gram-scalability and the late-stage modification of natural compounds. Mechanistic experiments suggest that this process involves in situ formation of an imine intermediate via base-promoted elimination of HF.

Fluorination of carbanions with N-fluoro-N-alkylsulfonamides

Process for fluorinating an organic carbanion, which process comprises contacting and reacting, in a dry inert atmosphere, the compound of the formula selected from STR1 wherein STR2 is the carbanion, M is a counter ion, and X is a halide and a selected N-flouro-N-alkylsulfonamide.