883107-68-4

Basic information

• Product Name: 6-chloro-2-fluoro-3-hydroxypyridine
• Synonyms: 6-chloro-2-fluoro-3-hydroxypyridine;6-Chloro-2-fluoropyridin-3-ol;2-FLUORO-6-CHLORO-3-HYDROXYPYRIDINE
• CAS NO: 883107-68-4
• Molecular Formula: C₅H₃ClFNO
• Molecular Weight: 147.5348232
• Mol File: 883107-68-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 336.0±37.0 °C(Predicted)
• Appearance: /
• Density: 1.517±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 4.46±0.10(Predicted)
• CAS DataBase Reference: 6-chloro-2-fluoro-3-hydroxypyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-2-fluoro-3-hydroxypyridine(883107-68-4)
• EPA Substance Registry System: 6-chloro-2-fluoro-3-hydroxypyridine(883107-68-4)

Safety Data

• Hazardous Substances Data: 883107-68-4(Hazardous Substances Data)

Usage

General Description

6-Chloro-2-fluoro-3-hydroxypyridine is a type of compound classified under the chemical category of organohalogens. Organohalogens are organic compounds which contain at least one halogen (fluorine, chlorine, bromine, iodine, astatine) atom. In the name, "6-Chloro" indicates the presence of a Chlorine atom, "2-Fluoro" denotes a Fluorine atom, and "3-hydroxypyridine" suggests the presence of a Hydroxy group (-OH) attached to a pyridine ring. It is typically used in pharmaceuticals and chemical research applications. Careful handling of this compound is necessary due to its possibly reactive nature, though specific properties, applications, and health effects may vary based on its application and concentration.

Upstream product

• 20885-12-5 2-chloro-6-fluoropyridine 
• 1256345-66-0 (6-chloro-2-fluoropyridin-3-yl)boronic acid 

Downstream Products

• 1335218-42-2 (5-bromo-2-fluorophenyl)(6-chloro-2-fluoro-3-(methoxymethoxy)pyridin-4-yl)methanol 
• 1335218-43-3 (5-bromo-2-fluorophenyl)(6-chloro-2-fluoro-3-(methoxymethoxy)pyridin-4-yl)methanone 
• 1335218-44-4 (5-bromo-2-fluorophenyl)(6-chloro-2-fluoro-3-hydroxypyridin-4-yl)methanone 

Relevant articles and documents

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AMINO -DIHYDROOXAZINE AND AMINO - DIHYDROTHIAZINE SPIRO COMPOUNDS AS BETA - SECRETASE MODULATORS AND THEIR MEDICAL USE

The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula (I): wherein A1, A2, A3, A4, A5, A6, R2, R7, X, Y and Z of Formula (I) are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula (I), intermediates and processes useful for the preparation of compounds of Formula (I).