88315-64-4Relevant articles and documents
Remote conformational responses to enantiomeric excess in carboxylate-binding dynamic foldamers
Eccles, Natasha,Le Bailly, Bryden A.F.,Della Sala, Flavio,Vitórica-Yrezábal, I?igo J.,Clayden, Jonathan,Webb, Simon J.
supporting information, p. 9331 - 9334 (2019/08/08)
A crystallographically characterised zinc(ii)-capped foldamer can sense the enantiomeric excess of scalemic carboxylate solutions, including those produced by enantioselective organocatalysis, and can relay this input signal along the foldamer body to a remote glycinamide group, which then provides an NMR spectroscopic output.
NOVEL HEPATITIS C VIRUS INHIBITORS
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Page/Page column 36, (2013/07/05)
The invention provides compounds of formula (I): wherein Rings A and A' are independently 5-membered optionally substituted aromatic heterocycles; Q is C(=O)NR1R1' or formula U is C(R4)2, O, S, S(=O)2, C(R4)2C(R4)2, CH2O, OCH2, CH2S, SCH2, CH2S(=O)2, S(=O)CH2 or C=C(Ru )2; X is CH2, CHR12, CR12R12, O, S, S(=O)2 or NRx; m is 0, 1, 2 or 3; n is 0, 1, 2 or 3; the other variables are as defined in the claims, which are of use in the treatment or prophylaxis of hepatitis C virus infection, and related aspects.
Total synthesis of (+)-brefeldin C, (+)-nor-Me brefeldin A and (+)-4-epi-nor-Me brefeldin A
Archambaud, Sylvie,Legrand, Frederic,Aphecetche-Julienne, Karine,Collet, Sylvain,Guingant, Andre,Evain
experimental part, p. 1364 - 1380 (2010/05/03)
A total synthesis of (+)-brefeldin C (BFC) and two brefeldin A (BFA) analogues - (+)-nor-Me BFA and (+)-4-epi-nor-Me BFA - has been developed. Key features of the syntheses include desymmetrization of meso anhydrides, a Carreira reaction to control the ab