883195-40-2

Basic information

• Product Name: 3-AMINO-5-CHLOROPHENOL
• Synonyms: 3-AMINO-5-CHLOROPHENOL
• CAS NO: 883195-40-2
• Molecular Formula: C₆H₆ClNO
• Molecular Weight: 143.57094
• Mol File: 883195-40-2.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 3-AMINO-5-CHLOROPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-5-CHLOROPHENOL(883195-40-2)
• EPA Substance Registry System: 3-AMINO-5-CHLOROPHENOL(883195-40-2)

Safety Data

• Hazardous Substances Data: 883195-40-2(Hazardous Substances Data)

Usage

Description

3-Amino-5-chlorophenol is an organic compound characterized by the presence of an amino group at the 3-position and a chloro substituent at the 5-position on a phenol ring. It exhibits unique chemical properties due to the presence of both the amino and chloro groups, making it a versatile molecule for various applications in chemical research and synthesis.

Uses

Used in Chemical Research:
3-Amino-5-chlorophenol is used as a research compound for studying its recyclization with benzoxazinones. This application is significant in understanding the chemical behavior and potential applications of such compounds in various fields.
Used in Organic Synthesis:
3-Amino-5-chlorophenol can be utilized as a building block or intermediate in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals. Its unique structure allows for further functionalization and modification, expanding its potential uses in the chemical industry.
Used in Analytical Chemistry:
Due to its distinct chemical properties, 3-Amino-5-chlorophenol can be employed as a reagent or reference compound in analytical chemistry for the detection, quantification, or identification of other substances. Its specific interactions with certain analytes can be leveraged to develop novel analytical methods or improve existing ones.

Upstream product

• 618-63-3 3-chloro-5-nitrophenol 
• 121-88-0 5-Nitro-2-aminophenol 
• 10272-06-7 3-chloro-5-methoxyaniline 
• 55910-07-1 1-chloro-3-methoxy-5-nitrobenzene 

Downstream Products

• 56962-04-0 3-bromo-5-chlorophenol 
• 885044-43-9 N-(3-chloro-5-hydroxyphenyl)acetamide 
• 883194-88-5 3-chloro-5-hydrazino-phenol 
• 932707-28-3 5-chloro-3-(4-chlorobenzyl)-2,4-dimethylquinolin-7-ol 
• 956488-69-0 4-(3-amino-5-chlorophenoxy)-3-nitropyridin-2-amine 
• 1446133-92-1 C₁₉H₁₇Cl₂N₃O₃*ClH 

Relevant articles and documents

SECOND GENERATION INHIBITORS OF MITOCHONDRIAL PERMEABILITY TRANSITION PORE WITH IMPROVED PLASMA STABILITY

The present invention provides compounds useful as mitochondrial permeability transition pore (mtPTP) inhibitors, the compounds being of Formula (I), or a pharmaceutically acceptable salt thereof wherein R11 is selected from the group of H, halogen, and C11-C33 alkyl; and R22 is selected from the group of H, CF33, and halogen; with the proviso that at least one of R11 and R22 is halogen or CF33.

Second-Generation Inhibitors of the Mitochondrial Permeability Transition Pore with Improved Plasma Stability

Excessive mitochondrial matrix Ca2+ and oxidative stress leads to the opening of a high-conductance channel of the inner mitochondrial membrane referred to as the mitochondrial permeability transition pore (mtPTP). Because mtPTP opening can lead to cell death under diverse pathophysiological conditions, inhibitors of mtPTP are potential therapeutics for various human diseases. High throughput screening efforts led to the identification of a 3-carboxamide-5-phenol-isoxazole compounds as mtPTP inhibitors. While they showed nanomolar potency against mtPTP, they exhibited poor plasma stability, precluding their use in in vivo studies. Herein, we describe a series of structurally related analogues in which the core isoxazole was replaced with a triazole, which resulted in an improvement in plasma stability. These analogues were readily generated using the copper-catalyzed “click chemistry”. One analogue, N-(5-chloro-2-methylphenyl)-1-(4-fluoro-3-hydroxyphenyl)-1H-1,2,3-triazole-4-carboxamide (TR001), was efficacious in a zebrafish model of muscular dystrophy that results from mtPTP dysfunction whereas the isoxazole isostere had minimal effect.

Substituted benzodiazepine ring compound and preparation method and application thereof

The invention discloses a substituted benzodiazepine ring compound and a preparation method and application thereof and further relates to a pharmaceutical composition and application of the compound. According to the substituted benzodiazepine ring compound, the effect of preventing or treating an immune inflammatory disease or tumor is achieved through activation of a selectively antagonistic or collaboratively excited NOD1/2 signal transduction pathway; the substituted benzodiazepine ring compound has a polypeptidase stability and is not degraded by polypeptidase in the organism.